血清4项肿瘤标志物联合检测诊断原发性肝癌的价值  

Value of combined detection of serum four tumor markers in diagnosing primary liver cancer

作　　者：冷俊[1] 秦兵[1] LENG Jun;QIN Bing(Department of Clinical Laboratory,Chongming Branch of Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University,Shanghai,222152)

机构地区：[1]上海交通大学医学院附属新华医院崇明分院检验科,上海202150

出　　处：《实用临床医药杂志》2020年第15期18-20,31,共4页Journal of Clinical Medicine in Practice

基　　金：上海市科委产学研医合作项目(17DZ1930309)。

摘　　要：目的探讨血清癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原125(CA125)和糖类抗原199(CA199)联合检测诊断原发性肝癌的价值。方法选取41例原发性肝癌患者为肝癌组,39例肝部良性病变患者为良性组,以及40例健康体检者为对照组。比较3组血清CEA、AFP、CA125、CA199水平及检测阳性率,计算4项指标联合检测诊断原发性肝癌的敏感度、特异度和准确度。结果肝癌组血清CEA、AFP、CA125和CA199水平均高于良性组和对照组,差异有统计学意义(P<0.05)。肝癌组血清CEA、AFP、CA125、CA199检测阳性率以及联合检测阳性率高于良性组和对照组,差异有统计学意义(P<0.05)。血清CEA、AFP、CA125、CA199联合检测的诊断敏感度、准确度均高于各项指标单独检测的结果,差异有统计学意义(P<0.05)。联合检测特异度为89.87%,与单项检测结果比较,差异无统计学意义(P>0.05)。结论血清CEA、AFP、CA125和CA199联合检测对诊断原发性肝癌有重要价值,可提高检测效能。Objective To explore the value of combined detection of serum carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),carbohydrate antigen 125(CA125)and carbohydrate antigen199(CA199)in diagnosing primary liver cancer.Methods A total of 41 patients with primary liver cancer were selected as liver cancer group,the 39 patients with benign liver disease were selected as benign group,and 40 healthy people with physical examination were selected as control group.The serum CEA,AFP,CA125 and CA199 levels and positive rates were compared among the three groups,and the sensitivity,specificity and accuracy of combined detection of the four indicators in the diagnosis of primary liver cancer were calculated.Results The serum levels of CEA,AFP,CA125 and CA199 in the liver cancer group were significantly higher than those in the benign group and the control group(P<0.05).The positive rates of CEA,AFP,CA125,CA199 and their combined detection in the liver cancer group were significantly higher than those in the benign group and the control group(P<0.05).The sensitivity and accuracy of combined detection of serum CEA,AFP,CA125 and CA199 were significantly higher than the results of single detection of each index(P<0.05).The specificity of combined detection was 89.87%,which showed no significant difference compared with single detection of each index(P>0.05).Conclusion The combined detection of serum CEA,AFP,CA125 and CA199 is of great value in the diagnosis of primary liver cancer,which can improve the detection efficiency.

关 键 词：癌胚抗原 甲胎蛋白 糖类抗原125 糖类抗原199 原发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤] R446.112[医药卫生—临床医学]