MyD88在肿瘤免疫耐受及免疫治疗中的研究进展  

Research Progress of MyD88 in Tumor Immune Tolerance and Immunotherapy

作　　者：赵婷 潘云 高波 ZHAO Ting;PAN Yun;GAO Bo(School of Basic Medicine Sciences,Dali University,Dali 671000,China;School of Clinical Medicine,Dali University,Dali 671000,China)

机构地区：[1]大理大学基础医学院,云南大理671000 [2]大理大学临床医学院,云南大理671000

出　　处：《中国肿瘤》2020年第9期695-700,共6页China Cancer

基　　金：国家自然科学基金(81660037,81960042);云南省科学研究基金(云教科[2016]37,2019Y0268);校级科研基金(理大校发[2019]13)。

摘　　要：MyD88作为一种通用的信号衔接蛋白,调节大多数Toll样受体(TLR)和白细胞介素1受体(IL-1R)级联的信号传导,参与介导先天免疫,调节炎症微环境和肿瘤微环境。通过TLR/MyD88信号途径,MyD88直接或间接地影响多种下游的免疫因子分泌,诱导肿瘤细胞和/或免疫细胞分泌蛋白或表面分子改变,同时引起肿瘤组织局部免疫细胞种类、数量及功能的改变,导致炎症微环境恶化及肿瘤微环境重塑,最终引起肿瘤免疫耐受和免疫逃逸。MyD88在肿瘤免疫治疗中具有双重作用,一方面通过分泌免疫抑制因子,抑制疗效;另一方面将MyD88信号与嵌合抗原受体(CAR)T细胞、特异性抗原肽等新兴疗法结合,大大提高肿瘤免疫治疗的效率。MyD88的上述作用使其成为多种恶性肿瘤极具前景的诊疗靶点。MyD88,as a universal signal adaptor protein,regulates the signal transduction of most toll like receptor(TLR)and interleukin-1 receptor(IL-1R)cascades,and participates in mediating innate immunity,as well as regulates inflammatory microenvironment and tumor microenvironment.Through TLR/MyD88 signaling pathway,MyD88 directly or indirectly affects the secretion of a variety of downstream immune factors,induces changes in protein or surface molecules secreted by tumor cells and/or immune cells,and at the same time,causes changes in the type,number and function of local immune cells in tumor tissue,leading to the deterioration of inflammatory microenvironment and tumor microenvironment remodeling,which results in the tumor immune tolerance and immune escape.MyD88 has dual functions in tumor immunotherapy.On one hand,it inhibits the therapeutic effect by secreting immunosuppressive factors;on the other hand,it combines MyD88 signal with new therapies,such as CAR-T cells and specific peptide,which greatly improves the therapeutic effect of tumor immunotherapy.The combination of functions above makes MyD88 a promising target for diagnosis and treatment of many kinds of malignant tumors.

关 键 词：MYD88 肿瘤微环境 免疫治疗 肿瘤免疫耐受 

分 类 号：R735.3+4[医药卫生—肿瘤]