中国汉族人群细胞色素P_(450)2E1基因多态性与肺癌的相关性  

Relationship between Cytochrome P450 2E1 Genetic Polymorphism and Lung Cancer in Chinese Han Subjects

作　　者：黄跃华[1] 王庆松[2] 朱莉贞[2] 张远[1] 

机构地区：[1]北京大学基础医学院药理系,北京100083 [2]北京胸部肿瘤结核病医院内科,北京101149

出　　处：《中国临床药理学杂志》2000年第5期350-352,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的：研究中国汉族人群中细胞色素P4502E1基因多态性与肺癌的相关性。方法：应用PCR-RFLP方法研究了260例正常对照者和54例肺癌患者细胞色素P4502E1 RsaI基因多态性。结果：对照组A型（c1c1）152例，B型（c1/c2）101例，C型(c2/c2)7例，分别占58.5%, 38.8%和2.7%，c2等位基因频率为0.22；肺癌组A型（c1c1）25例，B型（c1/c2）26例，C型(c2/c2) 3例，分别占46.3%, 48.1%和5.6%, c2等位基因频率为0.30。结论：中国汉族人群中细胞色素P4502E1基因多态性与肺癌无明显相关性。OBJECTIVE: To study the relationship between cytochrome P450 2E1 (CYP2E1) genetic polymorphism (RsaI) and lung cancer in Chinese Han subjects. METHODS: 260 Healthy controls and 54 lung cancer patients were studied using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: In control group, type A(c1/c1), type B(c1/c2), and type C(c2/c2) were 152(58.5%) , 101(38.8%) , and 7(2.7%) subjects respectively. The c2 allele frequency was 0.22. In lung cancer patients, type A(c1/c1), type B(c1/c2), and type C(c2/c2) were 25(46.3%), 26(48.1%), and 3(5.6%) subjects respectively. The c2 allele frequency was 0.30. CONCLUSIONS: There was not significant relationship between cytochrome P450 2E1 genetic polymorphism and lung cancer in Chinese Han subjects.

关 键 词：汉族人群 相关性 中国 细胞色素P450 基因多态性 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]