ETS转录因子家族在消化道肿瘤中的作用研究进展  

The progress of the research on the role of ETS transcription factor family in gastrointestinal tumor

作　　者：覃小珊[1,2] 张彩灵 黄赞松 QIN Xiaoshan;ZHANG Cailing;HUANG Zansong(Department of Gastroenterology,the Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi,Baise 533000,China;Graduate School,Youjiang Medical Univesity for Nationalities,Guangxi,Baise 533000,China;Guangxi Clinical Medical Research Center for Hepatobiliary Diseases,Guangxi,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院消化内科,广西百色533000 [2]右江民族医学院研究生学院,广西百色533000 [3]广西肝胆疾病临床医学研究中心,广西百色533000

出　　处：《中国医药科学》2020年第16期26-31,共6页China Medicine And Pharmacy

基　　金：广西自然科学基金资助项目(2014GXNSFAA118143);广西科技基地和人才专项(广西肝胆疾病临床医学研究中心研究课题)(桂科AD17129025);2017年度广西医药卫生自筹经费计划课题(Z20170224);广西研究生教育创新计划项目(YCSW2020235)。

摘　　要：ETS转录因子是细胞内最大的转录调控因子家族之一。它调控许多参与胚胎发育、细胞增殖、凋亡、分化、迁移、侵袭、转移以及耐药性的生物途径,影响着机体的生理、病理过程,在造血系统、免疫系统、内分泌系统等多个系统发挥重要作用。近年来的研究发现它通过调控肿瘤细胞周期、介导血管生成及浸润转移等方面广泛参与消化道肿瘤的发生发展过程。本文就ETS转录因子家族在不同系统中的作用及对消化道肿瘤的影响相关研究进展予以综述,供消化道肿瘤基础与临床研究参考。ETS transcription factor family is one of the largest transcription regulatory factor families in cells.It regulates many biological pathways involved in embryonic development,cell proliferation,apoptosis,differentiation,migration,invasion,metastasis and drug resistance,affects the physiological and pathological processes of the body,and plays an important role in many systems such as hematopoietic system,immune system,and endocrine system,etc.The studies in recent years have found that it is widely involved in the occurrence and development of digestive tract tumors by regulating tumor cell cycle,mediating angiogenesis and infiltration and metastasis,etc.This paper reviews the research progress on the role of ETS transcription factor family in different systems and its influence on digestive tract tumors,so as to provide a reference for basic and clinical research of digestive tract tumors.

关 键 词：ETS转录因子 生理作用 消化道肿瘤 调节作用 分子机制 生物学行为 

分 类 号：R735[医药卫生—肿瘤]