免疫吸附疗法对急性炎症性脱髓鞘性多发性神经病的效果分析  

Effect of Immunoadsorption Therapy on Acute Inflammatory Demyelinating Polyneuropathy

作　　者：陈雪玲 钟洁[2] 冯跃明 程飞 CHEN Xue-ling;ZHONG Jie;FENG Yue-ming;CHENG Fei(Department of Neurology,Qionghai People's Hospital,Qionghai,Hainan Province,571400 China;Department of Brain Diseases,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning,Guangxi,530023 China)

机构地区：[1]琼海市人民医院神经内科,海南琼海571400 [2]广西中医药大学第一附属医院脑病科,广西南宁530023

出　　处：《系统医学》2020年第16期53-55,共3页Systems Medicine

摘　　要：目的探讨免疫吸附疗法对急性炎症性脱髓鞘性多发性神经病(AIDP)的效果。方法选取琼海市人民医院神经内科2017年2月—2019年5月收治的108例AIDP患者,采用红蓝双色球法将其分为两组,各54例。其中,对照组采用血浆置换法治疗,观察组采用免疫吸附疗法治疗,比较两组治疗前后的炎症指标变化情况和治疗后1d、治疗后2周的效果。结果治疗前,观察组的肿瘤坏死因子(TNF-α)(35.49±11.26)μg/L、C反应蛋白(CRP)(16.19±5.52)mg/L与对照组的TNF-α(35.42±11.45)μg/L、CRP(16.28±5.14)mg/L比较差异无统计学意义(t=0.032、0.088,P>0.05);治疗后,观察组的TNF-α(21.24±7.09)μg/L、CRP(7.25±2.84)mg/L低于对照组的TNF-α(28.36±8.35)μg/L、CRP(11.54±3.37)mg/L,差异有统计学意义(t=4.776、7.153,P<0.05);观察组和对照组治疗后的TNF-α(t=7.870、3.661)、CRP(t=10.583、7.484)低于该组治疗前,差异有统计学意义(P<0.05);观察组治疗后1 d的总有效率51.85%高于对照组14.81%,差异有统计学意义(χ2=16.666,P<0.05);观察组治疗后2周的总有效率75.93%与对照组72.22%比较差异无统计学意义(χ2=0.192,P>0.05)。结论免疫吸附疗法治疗AIDP能够有效降低患者炎症指标水平,患者感觉和肌力明显改善,预后恢复良好,值得临床参考借鉴。Objective To explore the effect of immunoadsorption therapy on acute inflammatory demyelinating polyneuropathy(AIDP).Methods A total of 108 patients with AIDP who were admitted to the Department of Neurology of Qionghai People's Hospital from February 2017 to May 2019 were selected and divided into two groups of 54 patients using the red and blue color ball method.Among them,the control group was treated with plasma exchange method,and the observation group was treated with immunoadsorption therapy,comparing the changes of inflammation indexes before and after treatment between the two groups and the effects of 1d after treatment and 2 weeks after treatment.Results Before treatment,the tumor necrosis factor(TNF-α)(35.49±11.26)μg/L,C-reactive protein(CRP)(16.19±5.52)mg/L of the observation group and the control group TNF-α(35.42±11.45)μg/L/L,CRP(16.28±5.14)mg/L had no statistically significant difference(t=0.032,0.088,P>0.05);after treatment,the observation group’s TNF-α(21.24±7.09)μg/L,CRP(7.25±2.84)mg/L is lower than TNF-α(28.36±8.35)μg/L,CRP(11.54±3.37)mg/L,the difference was statistically significant(t=4.776,7.153,P<0.05)of the control group;observation group and control group The TNF-α(t=7.870,3.661)and CRP(t=10.583,7.484)after treatment were lower than that of this group before treatment(P<0.05);the total effective rate 1 day after treatment in the observation group was 51.85%higher than that in the control group 14.81%,the difference was statistically significant(χ2=16.666,P<0.05);There was no statistically significant difference between the observation group’s total effective rate 2 weeks after treatment 75.93%and the control group 72.22%(χ2=0.192,P>0.05).Conclusion Immunoadsorption therapy can effectively reduce the level of inflammation in patients with AIDP.The patient's sensation and muscle strength are significantly improved,and the prognosis is recovered well.

关 键 词：免疫吸附疗法 急性炎症性脱髓鞘性多发性神经病 血浆置换法 

分 类 号：R745[医药卫生—神经病学与精神病学]