黄芪多糖对老年肺癌患者化疗期间骨髓抑制的改善作用及造血干细胞的影响  

Therelated effects of astragaluspolysaccharides on the improvement of bone marrow suppression and hematopoietic stem cells during chemotherapy in elderly patients with lung cancer

作　　者：巩雅宁 王帅 张静[1] 刘义冰 田新利[1] GONG Ya-ning;WANG Shuai;ZHANG Jing;LIU Yi-bing;TIAN Xin-li(First Affiliated Hospital of Xingtai Medical College(Xingtai First Hospital),054000)

机构地区：[1]邢台医学高等专科学校第一附属医院(邢台市第一医院),河北邢台054000

出　　处：《海南医学院学报》2020年第19期1468-1473,共6页Journal of Hainan Medical University

基　　金：邢台市科技计划项目任务书(2019ZC206)。

摘　　要：目的:探究黄芪多糖(APS)对老年肺癌患者化疗期间骨髓抑制及造血干细胞的影响。方法:随机数表法将邢台市第一医院2019年1~12月初治的120例老年肺癌患者均分为治疗组与对照组,均接受培美曲塞+卡铂化疗,治疗组化疗同时给予APS治疗。化疗2周期后评价疗效,观察骨髓抑制情况,且化疗前、化疗2周期后对两组中医症候积分、外周血T淋巴细胞亚群指标、L-选择素(CD62L)、巨噬细胞分化抗原-1(Mac-1)水平进行了测定。结果:两组有效率(RR)比较,差异无统计学意义(P>0.05);治疗组疾病控制率(DCR)明显高于对照组(P<0.05);治疗组白细胞减少程度明显小于对照组(P<0.05);治疗组血小板及血红蛋白减少1级+2级比例,均明显低于对照组(P<0.05);与化疗前对比,两组化疗后中医症候总积分、血清CD62L、Mac-1水平均明显下降且治疗组均明显低于对照组(P<0.05);治疗组化疗后CD3^+、CD4^+、CD4^+/CD8^+较化疗前均明显上升,且均高于对照组,CD8^+较化疗前明显下降,且低于对照组(P<0.05),对照组化疗前后T淋巴细胞亚群指标对比差异无统计学意义(P>0.05)。结论:黄芪多糖能提高老年肺癌患者化疗效果,改善骨髓抑制情况,这可能与黄芪多糖明显增强机体免疫功能,降低CD62L、Mac-1水平有关。Objective:To investigate the effects of astragalus polysaccharides(APS)on bone marrow suppression and hematopoietic stem cells during chemotherapy in elderly patients with lung cancer.Methods:A total of 120 elderly patients with lung cancer treated in the First Hospital of Xingtai city from January 2019 to early December 2019 were divided into the treatment group and the control group by the random number table method,all of whom received pemetrexed+carboplatin chemotherapy,and the treatment group was treated with APS at the same time.The efficacy was evaluated after 2 cycles of chemotherapy,bone marrow suppression was observed,and levels of TCM symptoms score,peripheral blood T lymphocyte subgroup index,L-selectin(CD62L)and macrophage differentiation antigen-1(Mac-1)were measured before and after 2 cycles of chemotherapy.Results:The response rate(RR)was 56.67%in the treatment group and 45.00%in the control group,with no statistically significant difference(P>0.05);the disease control rate(DCR)in the treatment group was 81.67%,which was significantly higher than 65.00%in the control group(P<0.05);the reduction degree of leukopenia in the treatment group was significantly lower than that in the control group(P<0.05);the treatment group had a platelet reduction of grade 1+2 at a rate of 40.00%,and hemoglobin reduction of grade 1+2 at a rate of 28.33%,which were significantly lower than the control group at 65.00%and 58.33%(P<0.05).Compared with those before chemotherapy,the total score of TCM symptoms,serum CD62L and Mac-1 levels in the two groups all decreased significantly after chemotherapy,and they were significantly lower in the treatment group than in the control group(P<0.05).After chemotherapy,CD3^+,CD4^+and CD4^+/CD8^+in the treatment group increased significantly and they were all higher in the treatment group than in the control group;while CD8^+decreased significantly and was lower in the treatment group than in the control group(P<0.05).There was no statistically significant difference in T lymphocyte

关 键 词：黄芪多糖 老年 肺癌 骨髓抑制 造血干细胞 

分 类 号：R734.2[医药卫生—肿瘤]