甲状腺癌患者1,25-(OH)2D3水平变化及临床价值  

Changes and clinical value of 1,25-(OH)2D3 in thyroid cancer patients

作　　者：郑倩[1] 唐哲[1] 彭葆坤[1] 黄洁杰 李清竹[1] 颜穗珺 陈红艳 Zheng Qian;Tang Zhe;Peng Baokun(Yan'an Hospital of Kunming Medical University,KunmingYunnan 650051,China)

机构地区：[1]昆明医科大学附属延安医院,云南昆明650051

出　　处：《云南医药》2020年第5期425-428,共4页Medicine and Pharmacy of Yunnan

摘　　要：目的探究甲状腺癌(TC)患者1,25-(OH)2D3水平变化及临床价值。方法前瞻性的选取2014年6月-2016年9月我院肿瘤科收治的69例TC患者作为研究对象,收集患者资料;另选同时期体检健康的30例作为正常对照组。采用化学发光法检测所有入试者1,25-(OH)2D3水平,比较临床特征与1,25-(OH)2D3水平之间关系,并采用Pearson行相关性分析。结果在TC与健康人群的比较中发现,TC患者1,25-(OH)2D3水平显著低于健康人群(t=8.720,P<0.05)。在不同临床资料比较中,TC患者在性别、年龄上1,25-(OH)2D3水平差异无统计学意义(P>0.05)。但在病理类型中,3组患者1,25-(OH)2D3水平比较差异显著(F=19.413,P<0.05),其中以未分化甲状腺癌(ATC)患者1,25-(OH)2D3水平最低,而乳头状甲状腺癌(PTC)患者1,25-(OH)2D3水平最高;在TNM分期中,4组患者1,25-(OH)2D3水平比较差异显著(F=25.189,P<0.05),以TNM分期越高,其1,25-(OH)2D3水平越低。在Pearson相关性分析中,1,25-(OH)2D3水平与病理类型与TNM分期均呈现负相关,相关系数分别为-0.777、-0.827。结论TC患者中1,25-(OH)2D3水平显著低于健康人群水平,且在不同病理类型和TNM分期中均有显著差异,并以未分化类型和TNM分期越高其水平下降最为显著;可能提示,临床治疗可考虑引入1,25-(OH)2D3辅助手段。Objective To investigate the changes and clinical value of 1,25-(OH)2D3 level in TC patients.Methods 69 TC patients admitted to the oncology department of our hospital from June 2014 to September 2016 were prospectively selected as the research objects.Information about that patient was collect.Another 30 healthy subjects in the same period were selected as the normal control group.Using chemiluminescence method to test subjects 1,25-(OH)2D3 levels.And the relationship between clinical features and 1,25-(OH)2D3 levels was compared.Use the correlation analysis of the Pearson line.Results It was found in the comparison between TC and healthy population.The level of 1,25-(OH)2D3 in TC patients was significantly lower than that in healthy people(t=8.720,P <0.05).In the comparison of different clinical data.It was found that TC patient had no statistically significant difference in sex,age,1,25-(OH)2D3 levels(P> 0.05).But in the pathological type.It was found that that level of 1,25-(OH)2D3 in group 3patients were significantly different(F=19.413,P <0.05).The ATC patients 1,25-(OH)2D3 levels were the lowest,while the patients 1,25-(OH)2D3 were the highest in PTC patients.In TNM stage,that comparative difference of 1,25-(OH)2D3 levels in four patient were significant(F=25.189,P <0.05).The higher the stage,the lower the level of 1,25-(OH)2 D3.In Pearson correlation analysis,1,25-(OH)2D3 levels is negatively related to the pathological type and TNM stage were presented.The correlation coefficients were -0.777 and -0.827,respectively.Conclusion The level of 1,25-(OH)2D3 in TC patients was significantly lower than that in healthy people.There were significant differences in different pathological types and TNM stages.Not differentiated type and TNM staging,the higher the level of decline significantly.It might suggest that clinical treatment would consider introducing 1,25-(OH)2D3 auxiliary means.

关 键 词：甲状腺癌 1 25-(OH)2D3 维生素D 临床价值 

分 类 号：R736.1[医药卫生—肿瘤]