26S蛋白酶体ATP酶亚基2在非小细胞肺癌患者中的表达及其与预后的关系  

Expression of Proteasome 26S Subunit ATPase 2 in Non-Small Cell Lung Cancer Patients and Its Relationship with Prognosis

作　　者：吴伟铭[1] 赵天成[1] 郭翔 杨异[1] Wu Weiming;Zhao Tiancheng;Guo Xiang;Yang Yi(Department of Thoracic Surgery,Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院胸外科,上海200233

出　　处：《肿瘤预防与治疗》2020年第9期767-774,共8页Journal of Cancer Control And Treatment

基　　金：上海市促进市级医院临床技能与临床创新能力三年行动计划(编号:16CR2013A)。

摘　　要：目的:研究26S蛋白酶体ATP酶亚基2(proteasome 26S subunit ATPase 2,PSMC2)蛋白在非小细胞肺癌(non-small cell lung cancer,NSCLC)患者中的表达情况及其与NSCLC细胞患者预后的关系。方法:采用免疫组化方法分别检测58例NSCLC患者癌组织和癌旁组织中的PSMC2表达情况。从临床特征和病理特征两方面进行两组患者差异的比较。通过电话随访方式了解这58例患者手术后的生存状况,使用Kaplan-Meier法绘制生存曲线,比较两组患者的生存差异。Logistic回归分析PSMC2表达与临床病理参数的关系,同时使用COX回归进行单因素和多因素分析包括PSMC2在内的所有的临床病理特征与患者生存的关系。结果:一般临床资料比较发现,随着吸烟指数的升高,PSMC2阳性患者的人数与PSMC2阴性人数比值也随之增高。另外,在肿瘤最大直径和肿瘤分化程度上,PSMC2阴性患者与PSMC2阳性患者之间的差异有统计学意义(均P<0.05)。Kaplan-Meier分析显示,PSMC2阴性患者的总生存期(62个月vs 56个月,P=0.004)和无进展生存期(48个月vs 45个月,P=0.043)均优于PSMC2阳性患者,差异有统计学意义。Logistic回归分析显示PSMC2表达仅与肿瘤分化程度有关(OR:3.511,CI:1.498~8.227,P=0.004)。单因素分析表明PSMC2高表达(HR:2.950,CI:1.335~6.525,P=0.007)和肿瘤分化程度(HR:2.045;CI:1.210~3.461,P=0.008)与NSCLC患者的不良生存预后相关:而多因素检验分析进一步证明PSMC2阳性表达与NSCLC患者的不良结局相关(HR:3.165;CI:1.439~6.961,P=0.034)。结论:PSMC2蛋白在NSCLC患者中有不同程度的表达,其表达的阳性程度与肺癌的恶性程度有一定关系,单因素和多因素分析均显示其阳性表达与患者的不良预后有关。Objective:To investigate the expression of proteasome 26S subunit ATPase 2(PSMC2)in non-small cell lung cancer(NSCLC)patients and its relationship with prognosis.Methods:Immunohistochemistry was used to detect the expression and location of PSMC2 in tumor and adjacent tissues from 58 NSCLC patients assigned to the PSMC2-positive group and the PSMC2-negative group.Clinicopatho-logical features of patients in two groups were compared.Sur-vival of the 58 patients were followed up by telephone,the Kaplan-Meier was used to compare the survival in two groups.Logistic regression was used to analyze the relationship between PSMC2 expression and clinicopathological parameters.Cox regression was used to perform univariate and multivariate analy-ses of the relationship between clinicopathological parameters and survival of the patients.Results:The higher the smoking index was,the higher the PSMC2-positive patients/PSMC2-negative patients ratio was.There were significant differences in maximum tumor diameter and tumor differentiation degree between PSMC2-positive patients and PSMC2-negative patients(P<0.05).Kaplan-Meier survival analysis revealed that the overall survival of PSMC2-negative patients was better than that of PSMC2-positive patients(56 months vs 48 months,P=0.004);and the progression-free survival of PSMC2-negative pa-tients was also better than that of PSMC2-positive patients(48 months vs 45 months,P=0.043).Logistic regression analy-sis showed that PSMC2 expression was correlated to tumor differentiation(OR:3.511,95%CI:1.498-8.227,P=0.004).Univariate analysis showed that high PSMC2 expression(HR:2.95,95%CI:1.335-6.525,P=0.007)and tumor differentiation(HR:2.045,95%CI:1.210-3.461,P=0.008)were poor prognostic factors;multivariate analysis showed that the positive expression of PSMC2 could be used as an independent prognostic factor to predict the poor outcome of NSCLC(HR:3.165,95%CI:1.439-6.961,P=0.034).Conclusion:PSMC2 is differently expressed in patients with NSCLC.The positive expression of PSMC2 in NSCLC patie

关 键 词：26S蛋白酶体 PSMC2蛋白 非小细胞肺癌 预后 

分 类 号：R734.2[医药卫生—肿瘤] R730.7[医药卫生—临床医学]