胸腹腔镜联合食管癌根治术对食管癌患者免疫功能的影响  

The effect of thoracoscopic and laparoscopic esophagectomy on immunity function of patients with esophageal cancer

作　　者：王武[1] 谢金标[1] 杨天宝[1] 黄国忠[1] 陈鹏飞 WANG Wu;XIE Jinbiao;YANG Tianbao;HUANG Guozhong;CHEN Pengfei(Department of Cardiothoracic Surgery,the Affiliated Hospital of Putian University,Putian 351100,Fujian,China)

机构地区：[1]莆田学院附属医院胸心外科,福建莆田3511000

出　　处：《癌症进展》2020年第18期1889-1891,共3页Oncology Progress

基　　金：福建省莆田市科学技术局项目(2018S3F019)。

摘　　要：目的探讨胸腹腔镜联合食管癌根治术对食管癌患者免疫功能的影响。方法根据治疗方法的不同将90例食管癌患者分为研究组和常规组,研究组患者接受胸腹腔镜联合食管癌根治术,常规组患者接受传统食管癌手术。比较两组患者术前、术后当天、术后3天及术后10天的免疫功能指标(CD3+、CD4+、CD8+、CD4+/CD8+),比较两组患者的术后并发症发生率。结果术前,两组患者的免疫功能指标CD3+、CD4+、CD8+、CD4+/CD8+比较,差异均无统计学意义(P﹥0.05)。术后当天,两组患者的CD3+、CD4+、CD8+、CD4+/CD8+均降低;术后3天,两组患者的CD3+、CD4+、CD8+均升高;术后10天,两组患者的CD3+、CD4+、CD8+均继续升高。术后当天、术后3天、术后10天,研究组患者的CD3+、CD4+、CD8+、CD4+/CD8+均高于常规组,差异均有统计学意义(P﹤0.05)。研究组患者的并发症发生率低于常规组,差异有统计学意义(P﹤0.05)。结论胸腹腔镜联合食管癌根治术较传统食管癌手术可以减轻对免疫细胞的抑制作用,降低并发症发生率,临床实践效果理想。Objective To investigate the effect of thoracoscopic and laparoscopic esophagectomy on immune function of patients with esophageal cancer.Method 90 patients with esophageal cancer were divided into study group and conventional group according to different surgical methods.The study group received thoracoscopic and laparoscopic esophagectomy,while the conventional group received traditional esophageal cancer surgery.The immune function indexes(CD3+、CD4+、CD8+、CD4+/CD8+)were compared between the two groups before operation,on the same day after operation,3 days after operation and 10 days after operation,and the incidence of postoperative complications was compared between the two groups.Result There was no significant difference in preoperative immune function indexes(CD3+,CD4+,CD8+,CD4+/CD8+)between the two groups(P>0.05).On the same day after operation,the CD3+,CD4+,CD8+,CD4+/CD8+of the two groups decrease compared with that before operation,and showed a rising trend of CD3+,CD4+,CD8+in 3 days after operation,at 10 days after operation,the immune function indexes still rising.However,at each time node after operation,the CD3+,CD4+,CD8+,CD4+/CD8+of the study group were significantly higher compared with that of the conventional group(P<0.05).The incidence of complications in the study group was lower than that in the conventional group(P<0.05).Conclusion Thoracoscopic and laparoscopic esophagectomy can significantly reduce the inhibition of immune cells,reduce the rate of complications,and the clinical effect is ideal.

关 键 词：食管癌 胸腹腔镜联合食管癌根治术 免疫功能 并发症 

分 类 号：R735.1[医药卫生—肿瘤]