纤维支气管镜联合肺泡灌洗在胃癌术后合并重症肺部感染治疗中的效果分析  

Effect of fiberbronchoscopy combined alveolar lavage in the treatment of gastric cancer with severe postoperative pulmonary infection

作　　者：杨艳芳[1] 郝艳艳 王金磊[1] 赵宝利[1] YANG Yanfang;HAO Yanyan;WANG Jinlei;ZHAO Baoli(Department of Intensive Care Medicine,Jiyuan People’s Hospital,Jiyuan 454650,He’nan,China)

机构地区：[1]济源市人民医院重症医学科,河南济源4546500

出　　处：《癌症进展》2020年第18期1903-1906,共4页Oncology Progress

摘　　要：目的探讨胃癌术后合并重症肺部感染患者采用纤维支气管镜联合肺泡灌洗治疗的临床效果。方法根据治疗方案的不同将80例胃癌术后合并重症肺部感染患者分为观察组(n=42)和对照组(n=38),观察组给予纤维支气管镜联合肺泡灌洗治疗,对照组给予常规治疗。比较两组患者的临床疗效、血气指标、血清炎性因子水平和不良反应发生情况。结果观察组患者的临床疗效优于对照组(P﹤0.05)。治疗后,两组患者的血氧分压(PaO2)、血氧饱和度(SpO2)均高于本组治疗前,血二氧化碳分压(PaCO2)低于本组治疗前(P﹤0.05),且观察组患者的PaO2和SpO2均明显高于对照组,而PaCO2明显低于对照组(P﹤0.01)。治疗后,两组患者的C反应蛋白(CRP)、白细胞介素(IL)-6和IL-8水平均低于本组治疗前(P﹤0.05),且观察组患者的CRP、IL-6和IL-8水平均明显低于对照组(P﹤0.01)。两组患者的不良反应发生率比较,差异无统计学意义(P﹥0.05)。结论胃癌术后合并重症肺部感染患者采用纤维支气管镜联合肺泡灌洗治疗有较好的效果,值得临床使用。Objective To explore the clinical effect of fiberbronchoscopy combined alveolar lavage in the treatment of gastric cancer with severe postoperative pulmonary infection.Method 80 gastric cancer patients with severe postoperative pulmonary infection were divided into the observation group(n=42)and the control group(n=38),treated with fiberbronchoscopy combined alveolar lavage and the routine treatment respectively,and the clinical effect,blood gas index,serum inflammatory factor level and adverse reactions of the two groups were compared.Result The clinical effect of the observation group was better than that of the control group(P<0.05).The blood partial pressure of oxygen(PaO2)and pulse oxygen saturation(SpO2)after treatmentin the two groups were significantly higher than those before treatment,the blood partial pressure of carbon dioxide(PaCO2)lower than that before treatment(P<0.05),with higher PaO2 and SpO2 in the observation group than those in the control group,lower PaCO2 than that in the control group(P<0.01).The C-reactive protein(CRP),interleukin(IL)-6 and IL-8 after treatment in the two groups were significantly lower than those before treatment(P<0.05),with significantly lower levels in the observation group than those in the control group(P<0.01).There was no significant difference in the adverse reactions between the two groups(P>0.05).Conclusion Fibrobronchoscopy combined alveolar lavage is effective in the treatment of gastric cancer with severe postoperative pulmonary infection,which is worthy of clinical use.

关 键 词：胃癌 重症肺部感染 纤维支气管镜 肺泡灌洗 临床效果 

分 类 号：R735.2[医药卫生—肿瘤]