磁共振定量指标在原发性肝癌肝动脉栓塞治疗疗效评估中的应用  

Quantitative magnetic resonance imaging in evaluating therapeutic effect of hepatic artery embolization for primary liver cancer

作　　者：闫瑞芳[1] 周凤梅[1] 王红坡[1] 任继鹏[1] 韩东明[1] 谢北辰 YAN Ruifang;ZHOU Fengmei;WANG Hongpo;REN Jipeng;HAN Dongming;XIE Beichen(Department of MR,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,He’nan,China)

机构地区：[1]新乡医学院第一附属医院磁共振科,河南新乡4531000

出　　处：《癌症进展》2020年第18期1907-1909,1939,共4页Oncology Progress

摘　　要：目的探讨磁共振成像(MRI)在原发性肝癌介入治疗疗效评估中的价值。方法根据疗效的不同将88例行MRI检查及介入治疗的原发性肝癌患者分为有效组(n=55)和无效组(n=33)。比较两组患者的表观扩散系数(ADC)、快速扩散成分(Dfast)、血管通透性常数(Ktrans)变化值。结果有效组患者介入治疗前后的ADC变化值明显低于无效组患者,Dfast、Ktrans变化值均明显高于无效组患者(P﹤0.01)。ADC、Dfast、Ktrans变化值单独及联合预测原发性肝癌患者介入治疗疗效的ROC曲线下面积分别为0.873、0.821和0.870,灵敏度分别为82.00%、78.00%和80.00%,特异度分别为87.00%、80.00%和84.00%;三者联合预测原发性肝癌介入治疗疗效的ROC曲线下面积为0.892,灵敏度和特异度分别为85.00%和86.00%。结论MRI预测介入治疗疗效的灵敏度和特异度较高,在原发性肝癌介入治疗疗效评估中具有一定的应用价值,可提供客观的评估参数。Objective To investigate the value of magnetic resonance imaging(MRI)in evaluating the therapeutic effect of interventional therapy for primary liver cancer.Method 88 patients with primary liver cancer received MRI examination and interventional therapy were divided into the effective group(n=55)and ineffective group(n=33)according to therapeutic effect,and the changes of apparent diffusion coefficient(ADC),fast apparent diffusion coefficient(Dfast)and volume transfer constant(Ktrans)were compared.Result The ADC changes of the effective group before and after interventional therapy were significantly lower than those of the ineffective group,changes of Dfast and Ktrans significantly higher than those of the ineffective group(P<0.01).The area under ROC curve of ADC,Dfast and Ktrans for predicting the efficacy of interventional therapy were 0.873,0.821 and 0.870,the sensitivity 82.00%,78.00%and 80.00%,the specificity 87.00%,80.00%and 84.00%,respectively;the area under ROC curve of the three combined prognostic factors for interventional therapy of primary liver cancer was 0.892,the sensitivity and specificity were 85.00%and 86.00%,respectively.Conclusion MRI showed high sensitivity and specificity in predicting the efficacy of interventional therapy and has certain application value in the efficacy evaluation of interventional therapy for primary liver cancer and can provide objective parameters for evaluation.

关 键 词：磁共振成像 原发性肝癌 介入治疗 临床疗效 表观扩散系数 

分 类 号：R735.7[医药卫生—肿瘤]