WNT10B在肺鳞癌组织中表达升高  

Expression of WNT10B is increased in lung squamous cell carcinoma

作　　者：路琳 顾艺荀 徐兴祥 闵凌峰 陈彦亮 王霄霖 陈勇[1] LU Lin;GU Yi-xun;XU Xing-xiang;MIN Ling-feng;CHEN Yan-liang;WANG Xiao-lin;CHEN Yong(Department of Medical Oncology,Subei People s Hospital,Yangzhou 225001;Dalian Medical University,Dalian 116044,China;Department of Respiratory and Intensive Medical,Subei People s Hospital,Yangzhou 225001;Department of Thoracic Surgery,Subei People s Hospital,Yangzhou 225001)

机构地区：[1]苏北人民医院肿瘤科,江苏扬州225001 [2]大连医科大学,辽宁大连116044 [3]苏北人民医院呼吸与重症内科,江苏扬州225001 [4]苏北人民医院胸外科,江苏扬州225001

出　　处：《基础医学与临床》2020年第10期1389-1393,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81302015);江苏省自然科学基金(BK20191218);扬州市“十三五”科教强卫专项经费(ZDRC201846);扬州市自然科学基金(YZ2014044,YZ2016108);江苏省“科教强卫工程”青年医学人才专项基金(QNRC2016319)。

摘　　要：目的探讨WNT10B在肺鳞癌组织中的表达情况并探讨其与临床病理特征及预后之间的关系。方法选择上海芯超生物科技有限公司提供的75例附有随访信息的肺鳞癌组织芯片,免疫组化法检测WNT10B蛋白的表达;卡方检验分析WNT10B表达与肺鳞癌临床病理因素之间的联系;Kaplan-Meier生存分析和log-rank检验以及Cox比例风险模型分析WNT10B表达与肺鳞癌患者的预后。结果WNT10B在肺鳞癌组织中的表达均显著高于癌旁组织(P<0.001);WNT10B高表达与肿瘤T分期、肿瘤分化程度显著相关(P<0.05);WNT10B表达与肺鳞癌患者的预后具有相关性(P<0.05),WNT10B是肺鳞癌预后的独立相关因素(P<0.05)。结论WNT10B参与肺鳞癌的发生发展过程,有望成为肺鳞癌的一个新的肿瘤标志物及预后指标。Objective To detect the expression of WNT10B in lung squamous cell carcinoma and to explore the correlation with pathologic feature and prognosis.Methods We collected 75 cases tissue chips of lung squamous cell carcinoma with follow-up information from Shanghai Outdo Biotech Co.,ltd.The expression of WNT10B protein was examined by immunohistochemistry.Chi-squared test was used to analyze the correlation between WNT10B expression and pathological factors.Survival analysis,log-rank test and Cox proportional hazard model were employed to analyze the relationship between WNT10B expression and prognosis of patients.Results The expression of WNT10B in cancerous tissue was significantly higher than matched adjacent non-cancerous tissue(P<0.001).High expression of WNT10B was significantly correlated with T stage and tumor differentiation(P<0.05).WNT10B expression was correlated with the prognosis of patients(P<0.05)and WNT10B was an independent correlation factor for the prognosis(P<0.05).Conclusions WNT10B is involved in the occurrence and development of lung squamous cell carcinoma and is expected to be a new tumor marker and prognosis indicator.

关 键 词：肺鳞癌 组织芯片 WNT10B 预后 免疫组化 

分 类 号：R734[医药卫生—肿瘤]