心外膜在心肌梗死后心肌修复中作用的研究进展  

Progress of the role of epicardium in myocardial repair after myocardial infarction

作　　者：孙洋[1] 张岩[2] SUN Yang;ZHANG Yan(Department of Pathology,National Center for Cardiovascular Disease,Fuwai Hospital,CAMS&PUMC,Beijing 100037,China;Department of Cardiac Surgery,National Center for Cardiovascular Disease,Fuwai Hospital,CAMS&PUMC,Beijing 100037,China)

机构地区：[1]中国医学科学院北京协和医学院阜外医院国家心血管病中心病理科,北京100037 [2]中国医学科学院北京协和医学院阜外医院国家心血管病中心心外科,北京100037

出　　处：《基础医学与临床》2020年第10期1421-1425,共5页Basic and Clinical Medicine

基　　金：北京市自然科学基金(7162161)。

摘　　要：心外膜具有高度再生能力和多向分化潜能,能分泌多种信号分子,为心肌再生和组织重塑提供细胞基础和调节信号,是心肌再生领域的研究热点。本文主要阐述激活成人心外膜、调控心外膜分化和制作心外膜生物工程补片。以期基于心外膜的治疗早日应用于临床。The epicardium characterized by high regeneration ability and multidirectional differentiation potential,which can secrete a variety of signal molecules,and play a central role during myocardial infarction repair.Current research approaches aims to activate the adult epicardium,to regulate epicardial differentiation,and to make bioengineered epicardial patch to promote heart regeneration.In this Review,we describe recent advances in the biology of the epicardium and attempts using the epicardium as therapeutic targets for heart repair and regeneration.

关 键 词：心外膜 心脏 修复 再生 

分 类 号：R364[医药卫生—病理学]