胃泰胶囊质量标准提升及指纹图谱研究  

Study on quality standard improvement and fingerprintof weitai capsule

作　　者：王珺 梁承远 WANG Jun;LIANG Cheng-yuan(School of Food and Biological Engineering,Shaanxi University of Science&Technology,Xi′an 710021,China;Key Laboratory of Modern Research of Chinese and Tibetan Medicine of Qinghai Province,Qinghai Province Drug Inspection and Testing Institute,Xining 810000,China)

机构地区：[1]陕西科技大学食品与生物工程学院,陕西西安710021 [2]青海省药品检验检测院青海省中藏药现代化重点实验室,青海西宁810000

出　　处：《陕西科技大学学报》2020年第5期75-81,共7页Journal of Shaanxi University of Science & Technology

基　　金：青海省科技厅基础研究计划项目(2018-ZJ-T06);青海省科技厅科研技术条件平台-青海药品检验检测平台科研计划项目(2017-ZJ-Y40)。

摘　　要：对胃泰胶囊的质量标准进行合理化、科学化改进提升研究,建立了南寒水石的显微鉴别和没食子酸、丹参、五灵脂、檀香的薄层色谱鉴别,并采用高效液相色谱法测定丹酚酸B的含量,最后采用UPLC建立胃泰胶囊的指纹图谱.10批样品在显微和薄层色谱鉴别专属性良好,含量测定丹酚酸B进样量在0.0806~4.0310μg线性良好,平均加样回收率为95.74%,RSD为0.43%,指纹图谱相似度大于0.99.To improve the quality standard of Weitai capsule rationally and scientifically,the microscopic identification of nanhanhydrite and TLC identification of gallic acid,Salvia miltiorrhiza,wulingzhi and sandalwood were established.The content of salvianolic acid B was determined by HPLC.Finally,the fingerprint of Weitai capsule was established by UPLC.10 batches of samples were identified by micro and thin layer chromatography with good specificity.The injection volume of salvianolic acid B was 0.0806~4.0310μg,with good linearity.The average recovery was 95.74%,RSD was 0.43%,and the fingerprint similarity was greater than 0.99.

关 键 词：胃泰胶囊 质量标准提升 指纹图谱 

分 类 号：R914.5[医药卫生—药物化学]