胎盘多肽注射液对晚期卵巢癌TC方案化疗患者毒副反应及T细胞亚群的影响  

Effects of placental polypeptide injection on toxic and adverse reaction and T cell subsets in patients with advanced ovarian cancer receiving TC chemotherapy

作　　者：赵瑞琳 姚素丽 Zhao Ruilin;Yao Suli(Department of Obstetrics and Gynecology,Henan Shenhuo Group General Hospital,Yongcheng 476000,China)

机构地区：[1]河南神火集团职工总医院妇产科,永城476000

出　　处：《中国实用医刊》2020年第17期109-111,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨晚期卵巢癌紫杉醇+卡铂(TC)方案化疗患者联合胎盘多肽注射液辅助治疗对化疗毒副反应及T细胞亚群的影响。方法选取神火集团职工总医院2016年1月至2017年11月收治的晚期卵巢癌初次诊治患者90例,根据随机数字表法分为对照组与观察组,每组45例。所有患者均接受肿瘤细胞减灭术治疗,并在术后接受TC方案化疗;观察组在此基础上给予胎盘多肽注射液辅助治疗。治疗6个周期后,对比两组患者近期疗效、毒副反应发生情况及T细胞亚群各指标水平变化情况。结果治疗后,观察组治疗总有效率为71.11%(32/45),高于对照组的48.89%(22/45),P<0.05;观察组心脏毒性、肝肾功能损伤、骨髓抑制等毒副反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组CD3^+、CD4^+、CD8^+水平比较,差异未见统计学意义(P>0.05);治疗后,两组患者CD3^+、CD4^+、CD8^+水平均较治疗前降低(P均<0.05),且对照组T细胞亚群各指标水平均低于观察组,差异有统计学意义(P<0.05)。结论晚期卵巢癌患者术后接受TC方案化疗期间进行胎盘多肽注射液辅助治疗,可提升化疗疗效,减少化疗毒副反应,提高患者免疫功能。Objective To investigate the effects of paclitaxel+carboplatin(TC)chemotherapy combined with placental polypeptide injection on chemotherapy toxicity and T cell subsets in patients with advanced ovarian cancer.Methods A total of 90 patients with advanced ovarian cancer who were admitted to Henan Shenhuo Group General Hospital from January 2016 to November 2017 were selected,and divided into control group and observation group according to the random number table method,with 45 patients in each group.All patients were treated by aytoreductive surgery,and postoperative chemotherapy TC scheme.In addition,observation group was treated by placenta polypeptide injection auxiliary.After 6 cycles of treatment,the near future curative effect,occurrence of adverse reaction and index level changes of T cell subgroup were compared between the two groups.Results After treatment,the total effective rate of the observation group was 71.11%(32/45),which was higher than the 48.89%(22/45)of the control group,P<0.05;the incidence of toxic and adverse reactions,such as cardiac toxicity,liver and kidney function damage,bone marrow suppression,in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of cluster of differentiation(CD)3^+,CD4^+and CD8^+between the two groups(P>0.05).After treatment,the levels of CD3^+,CD4^+,CD8^+in the two groups were lower than those before treatment(all P<0.05),and the levels of T cell subsets in the control group were lower than those in the observation group,and the difference was statistically significant(P<0.05).Conclusions The treatment of placenta polypeptide injection can improve the efficacy of TC regimen chemotherapy,reduce the adverse reaction of chemotherapy and improve the immune function of patients with advanced ovarian cancer.

关 键 词：卵巢癌 胎盘多肽注射液 TC方案 毒副反应 T细胞亚群 

分 类 号：R737.31[医药卫生—肿瘤]