外周血调节性T细胞与炎性因子对乳腺癌切除术后感染的预测效果  

Effect of peripheral blood regulatory T cells and inflammatory factors on prediction of postoperative infection in breast cancer resection patients

作　　者：刘华 杨贵义[1] 汪彬[1] 彭成 张玲 LIU Hua;YANG Gui-yi;WANG Bin;PENG Cheng;ZHANG Ling(Suizhou Central Hospital,Suizhou,Hubei 441300,China)

机构地区：[1]随州市中心医院乳腺肛肠外科,湖北随州441300 [2]随州市曾都医院乳腺肛肠外科,湖北随州441300

出　　处：《中华医院感染学杂志》2020年第18期2804-2807,共4页Chinese Journal of Nosocomiology

基　　金：湖北省自然科学基金资助项目(2017CFB427)。

摘　　要：目的探讨外周血调节性T细胞与炎性因子对乳腺癌术后感染的预测效果。方法选取2014年1月-2019年12月于随州市中心医院接受乳腺癌切除术治疗患者为研究对象,44例术后发生感染患者为感染组,同期88例术后未发生感染的患者为未感染组。观察并比较两组患者术后第5天的炎性因子[超敏C-反应蛋白(High sensitivity C-reactive protein,hs-CRP)、白细胞介素6(Interleukin-6,IL-6)及白细胞介素10(Interleukin-10,IL-10)]和外周血调节性T细胞[CD4+、CD25+、CD127(low)]表达水平,分析指标诊断乳腺癌术后感染的临床价值。结果术后第5天感染组患者hs-CRP(8.87±3.15)mg/dl、IL-6(18.32±5.07)pg/ml及IL-10(7.41±1.26)pg/ml均高于未感染组(P<0.05);感染组患者CD4+(1.41±0.35)、CD25+(1.33±0.41)、CD127(low)(1.52±0.58)%水平均低于未感染组(P<0.05)。炎性因子对乳腺癌术后感染的预测具有较高的准确度(84.36%),但特异度较低(69.17%),外周血调节性T细胞对乳腺癌术后感染准确度较低(73.21%),但特异度较高(80.09%);二者联合检测的准确度、特异度及灵敏度均显著高于单独检测。结论乳腺癌根治术术后发生感染患者炎性因子水平升高,外周血调节性T细胞水平降低,二者联合检测用于乳腺癌术后感染的预测具有较高的准确度、灵敏度及特异度。OBJECTIVE To explore the effect of peripheral blood regulatory T cells and inflammatory factors on prediction of postoperative infection in breast cancer patients.METHODS The patients who received breast cancer resection in Suizhou Central Hospital from Jan 2014 to Dec 2019 were recruited as the study objects,44 patients who had postoperative infection were assigned as the infection group,88 patients who did not have postoperative infection were set as the non-infection group.The levels of inflammatory factors high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),interleukin-10(IL-10)and peripheral blood regulatory T cells[CD4+,CD25+,CD127(low)]were observed and compared between the two groups of patients,and the clinical value of the indexes in diagnosis of the postoperative infection was analyzed after the surgery for 5 days.RESULTS The levels of hs-CRP,IL-6 and IL-10 of the infection group were respectively(8.87±3.15)mg/dl,(18.32±5.07)pg/ml and(7.41±1.26)pg/ml after the surgery for 5 days,significantly higher than those of the non-infection group(P<0.05).The levels of CD4+,CD25+and CD127(low)of the infection group were respectively(1.41±0.35)%,(1.33±0.41)%and(1.52±0.58)%,significantly lower than those of the non-infection group(P<0.05).The accuracy of the inflammatory factors was 84.36%in prediction of the postoperative infection in the breast cancer patients,the specificity 69.17%;the accuracy of the peripheral blood regulatory T cells was 73.21%in prediction of the postoperative infection,the specificity 80.09%;the accuracy,specificity and sensitivity of the joint detection of the two types of indexes were remarkably higher than those of the detection of single index.CONCLUSION The levels of inflammatory factors of the breast cancer patients are elevated after the breast cancer resection,while the levels of peripheral blood regulatory T cells are reduced,and the accuracy,sensitivity and specific of the two types of indexes are high in prediction of the postoperative infection in the breast ca

关 键 词：调节性T细胞 炎性因子 乳腺癌 术后感染 

分 类 号：R737.9[医药卫生—肿瘤]