泮托拉唑治疗急性脑血管病伴应激性胃黏膜病变的临床效果  

Clinical effect of pantoprazole in the treatment of acute cerebrovascular disease with stress gastric mucosal lesions

作　　者：王柳毅[1] 吴瑞[1] 师媛[1] WANG Liuyi;WU Rui;SHI Yuan(Cardiovascular and Cerebrovascular Hospital,Yan'an University Affiliated Hospital,Yan'an 716000,China)

机构地区：[1]延安大学附属医院心脑血管专科医院,陕西延安716000

出　　处：《临床医学研究与实践》2020年第29期37-39,共3页Clinical Research and Practice

摘　　要：目的研究泮托拉唑治疗急性脑血管病伴应激性胃黏膜病变的临床效果。方法选取2018年12月至2019年12月我院收治的82例急性脑血管病伴应激性胃黏膜病变患者作为研究对象,根据治疗方法的不同将其分为法莫替丁组(41例,法莫替丁)和泮托拉唑组(41例,泮托拉唑)。比较两组患者的治疗效果。结果泮托拉唑组的出血停止时间、症状改善时间及住院时间均短于法莫替丁组(P<0.05)。治疗10 d后,两组的SOD水平、胃液pH、MTL水平均升高,GAS水平均降低,且泮托拉唑组优于法莫替丁组(P<0.05)。泮托拉唑组的治疗总有效率高于法莫替丁组(P<0.05)。泮托拉唑组的不良反应总发生率低于法莫替丁组(P<0.05)。结论泮托拉唑治疗急性脑血管病伴应激性胃黏膜病变的临床效果显著,可改善患者临床症状,降低不良反应发生率,值得临床推广应用。Objective To study the clinical effect of pantoprazole in the treatment of acute cerebrovascular disease with stress gastric mucosal lesions.Methods A total of 82 patients with acute cerebrovascular disease with stress gastric mucosal lesions admitted in our hospital from December 2018 to December 2019 were selected as the research objects,and the patients were divided into famotidine group(41 cases,famotidine)and pantoprazole group(41 cases,pantoprazole)according to different treatment methods.The clinical effects of the two groups were compared.Results The bleeding stop time,symptom improvement time and hospitalization time in the pantoprazole group were shorter than those in the famotidine group(P<0.05).After 10 days of treatment,the SOD level,gastric juice pH and MTL level in the two groups increased,and the GAS level decreased,and those in the pantoprazole group were better than the famotidine group(P<0.05).The total effective rate of treatment in the pantoprazole group was higher than that in the famotidine group(P<0.05).The total incidence of adverse reactions in the pantoprazole group was lower than that in the famotidine group(P<0.05).Conclusion Pantoprazole in the treatment of acute cerebrovascular disease with stress gastric mucosal lesions has significant clinical effect,it can improve the clinical symptoms of patients,reduce the incidence of adverse reactions,which is worthy of clinical promotion and application.

关 键 词：泮托拉唑 法莫替丁 急性脑血管病 应激性胃黏膜病变 

分 类 号：R573[医药卫生—消化系统]