Boosting Chemodynamic Therapy by the Synergistic Effect of Co‑Catalyze and Photothermal Effect Triggered by the Second Near‑Infrared Light  

作　　者：Songtao Zhang Longhai Jin Jianhua Liu Yang Liu Tianqi Zhang Ying Zhao Na Yin Rui Niu Xiaoqing Li Dongzhi Xue Shuyan Song Yinghui Wang Hongjie Zhang 

机构地区：[1]State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry(CIAC),Chinese Academy of Sciences(CAS),Changchun 130022,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [3]Department of Chemistry,Tsinghua University,Beijing 100084,People’s Republic of China [4]Department of Radiology,The Second Hospital of Jilin University,Changchun 130041,People’s Republic of China

出　　处：《Nano-Micro Letters》2020年第12期318-330,共13页纳微快报（英文版）

基　　金：This work was supported by the financial aid from the National Natural Science Foundation of China(Grant Nos.51502284,21834007,21521092,21590794,and 21673220);the Program of Science and Technology Development Plan of Jilin Province of China(No.20170101186JC);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB20030300);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2019232).

摘　　要：In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the important obstacle to further application in clinic.Herein,we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin(FeO/MoS2-BSA)with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared(NIR II)light.In the tumor microenvironments,the MoS2 nanosheets not only can accelerate the conversion of Fe3+ions to Fe2+ions by Mo4+ions on their surface to improve Fenton reaction efficiency,but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy(PTT).Consequently,benefiting from the synergetic-enhanced CDT/PTT,the tumors are eradicated completely in vivo.This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

关 键 词：Chemodynamic therapy Fenton reaction CO-CATALYSIS Photothermal effect NIR II biowindows 

分 类 号：R730.5[医药卫生—肿瘤]