阿尔茨海默病低频域脑电图定量分析  

Quantitative analysis of low-frequency electroencephalogram in Alzheimer’s disease

作　　者：闫艺 赵傲楠 仇颖慧 徐玮[1] 邓钰蕾[1] YAN Yi;ZHAO Ao-nan;QIU Ying-hui;XU Wei;DENG Yu-lei(Department of Neurology,Institute of Neurology,Ruijin Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200020,China)

机构地区：[1]上海交通大学医学院附属瑞金医院神经内科,上海200020

出　　处：《阿尔茨海默病及相关病杂志》2020年第3期215-220,共6页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：上海市自然基金面上项目(19ZR1432500)。

摘　　要：目的:探讨定量脑电图分析在阿尔茨海默病(Alzheimer’s disease,AD)中的应用价值。方法:我们纳入AD患者和认知功能正常老年人各26人。利用20导联的静息态脑电图检测受试者脑电波形。采用各频段功率值和加权相位延迟指数(weighted phase lag index,wPLI)分析各组人群中脑电波变化的差异性。结果:在AD组中,θ频段的功率显著高于对照组。另外,两组中功能连接的差异主要存在于低频段的δ和θ中。δ频段中AD病人的相位同步性减低,而在θ频段中AD病人的相位同步性明显强于对照组。结论:定量脑电图分析中显示,阿尔茨海默病病人脑内频率慢化和功能失连接的现象。Objective:To explore the application value of quantitative EEG analysis in Alzheimer’s disease(AD).Methods:We included 26 AD patients and 26 elderly people with normal cognitive function.The 20 scalp electrodes resting state electroencephalogram(EEG)was used to detect the brain waveform of the subjects.The power spectrum density of each band and the weighted phase lag index(wPLI)were used to analyze the differences in EEG changes among the groups.Results:In the AD group,the power spectrum density ofθband was significantly higher than that of the control group.In addition,the difference in functional connection between the two groups mainly exists in theδandθof the low frequency band.The phase synchronization of AD patients in theδband is reduced,while the phase synchronization of AD patients inθband is significantly stronger than that of the control group.Conclusion:Quantitative EEG analysis shows that the brain frequency of Alzheimer’s disease patients is slowed and the function connectivity is disconnected.

关 键 词：阿尔茨海默病 脑电图 功率谱 加权相位延迟指数 

分 类 号：R741[医药卫生—神经病学与精神病学]