顺铂联合伊立替康与顺铂联合依托泊苷对小细胞肺癌组织中VEGF、CD31及HIF-1表达水平的影响比较  

Comparison of the Effects of Cisplatin Combined with Irinotecan and Cisplatin Combined with Etoposide on the Expression Levels of VEGF,CD31 and HIF-1 in Tumor Tissues of Patients with Small Cell Lung Cancer

作　　者：陈诚 李宇青 冯高华 CHEN Cheng;LI Yuqing;FENG Gaohua(Zhangjiagang Hospital of Traditional Chinese Medicine,Zhangjiagang,215600)

机构地区：[1]江苏省张家港市中医医院,215600

出　　处：《实用癌症杂志》2020年第10期1656-1659,共4页The Practical Journal of Cancer

摘　　要：目的比较顺铂联合伊立替康与顺铂联合依托泊苷对小细胞肺癌(SCLC)患者肿瘤组织中血管内皮生长因子(VEGF)、内皮细胞黏附分子(CD31)及低氧诱导因子-1(HIF-1)表达水平的影响。方法选取SCLC患者102例,随机平均分为2组,每组51例。一组予以伊立替康联合顺铂治疗(IP组),一组予以依托泊苷联合顺铂治疗(EP组),观察并比较2组患者临床疗效、实验室指标、药物不良反应及生活质量评分。结果2组患者客观缓解率无统计学差异(86.27%vs 80.39%,P>0.05)。IP组的血小板减少发生率及腹泻发生率高于EP组(P<0.05)。治疗后,2组患者VEGF、CD31、HIF-1水平均降低,IP组CD31、HIF-1显著低于EP组(P<0.05),但2组的VEGF无统计学差异(P>0.05)。治疗后,2组患者的情绪功能、认知功能、生活质量及IP组的社会功能评分均升高(P<0.05),IP组的生活质量评分高于EP组(P<0.05)。结论IP治疗方案和EP治疗方案疗效及不良反应发生情况均相当,但IP治疗方案在抑制肿瘤细胞生长能力及改善患者生活质量方面优于EP治疗方案。Objective To compare the effects of cisplatin combined with irinotecan and cisplatin combined with etoposide on the expression levels of vascular endothelial growth factor(VEGF),endothelial cell adhesion molecule(CD31)and hypoxia inducible factor-1(HIF-1)in tumor tissues of patients with small cell lung cancer(SCLC).Methods 102 patients with SCLC were randomly divided into 2 groups with 51 cases in each group.IP group was treated with irinotecan combined with cisplatin,EP group was treated with etoposide combined with cisplatin.The clinical efficacy,laboratory indicators,drug toxicity and quality of life scores of the 2 groups were observed and compared.Results There was no significant difference in objective remission rate between the 2 groups(86.27%vs.80.39%,P>0.05).The incidence of thrombocytopenia and diarrhea in IP group were higher than those of EP group(P<0.05).After treatment,the levels of VEGF,CD31 and HIF-1 in patients of the 2 groups were all decreased,the levels of CD31 and HIF-1 in IP group were significantly lower than those of the control group(P<0.05),but there was no statistical difference in the level of VEGF between the 2 groups(P>0.05).After treatment,the scores of emotional function,cognitive function,quality of life and social function in the IP group were increased in both groups(P<0.05),and the score of quality of life in the IP group was higher than that of the EP group(P<0.05).Conclusion IP therapy and EP therapy have the same curative effect and adverse reactions,but IP therapy is superior to EP therapy in inhibiting tumor cell growth and improving patients'quality of life.

关 键 词：小细胞肺癌 顺铂 依托泊苷 伊立替康 内皮细胞黏附分子 低氧诱导因子-1 

分 类 号：R734.2[医药卫生—肿瘤]