“Buyi Ganshen”,a traditional Chinese medicine treatment,combined with dopa preparation for Parkinson’s disease therapy:a meta-analysis of randomized controlled trials  

作　　者：Xiao-Qian Hao Wen-Wen Si Ye Tian Jie Liu Yi-Chun Ji Xin-Rong Li Zi-Feng Huang Yu Zhu Dong-Feng Chen Wei-Hong Kuang Mei-Ling Zhu 

机构地区：[1]Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Guangzhou University of Chinese Medicine,Shenzhen 510800,China [2]Traditional Chinese Medicine Innovation Center,Shenzhen Baoan Traditional Chinese Medicine Hospital,Guangzhou University of Chinese Medicine,Shenzhen 518000,China [3]Department of Anatomy,The Research Center of Basic Integrative Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China [4]The Second Clinical Medical College,Guangdong Medical University,Dongguan 523808,China

出　　处：《TMR Aging》2020年第3期97-109,共13页衰老研究

基　　金：This study was financially supported by TCM Administration Project of Guangdong Province,China(No.20203010);Science and Technology Program of Guangdong,China(No.2020A151501325).

摘　　要：Traditional Chinese medicine Buyi Ganshen therapy combined with dopa preparation in the therapy of Parkinson’s disease could enhance the clinical safety and efficacy compared with dopa preparation along.The exact mechanism of how Buyi Ganshen works combined with dopa preparation still unknown and the enrolled articles quality was relatively inadequate,yet it could provide the reference in the clinical application and further studies.Background:To research the influence of“Buyi Ganshen”,a traditional Chinese medicine that commonly used in“Tonifying the Liver and the Kidney”,added dopa preparation for the therapy of Parkinson’s disease.Methods:This meta-analysis examined existing literature by searching 7 electronic databases(CNKI,WanFang,EMBASE,PubMed,Medline,the Cochrane Library,and the VIP database)from inception to December 2019.Randomized controlled trials evaluating the influence of“Buyi Ganshen”combined with dopa preparation for Parkinson’s disease were identified.The main results were clinical efficacy,UPDRS I(mental score),total unified Parkinson’s disease ratingscale score,UPDRS III(motor score),UPDRS II(activities of daily life),and UPDRS IV(complications of treatment).The subordinate results were the SPOCA-AUT scores,traditional Chinese medicine syndromes and other adverse reactions.The Review Manager 5.3 software was used to calculate the pooled estimate effect.The outcomes were showed as relative ratio with 95%confidence interval.The fixed or random model was elected based on the level of homogeneity among researches.The I2 was used to detected heterogeneity.The quality of the researches was also assessed.Results:The meta-analysis include 2,241 individuals from a total of 30 studies.These data suggested that the therapy of Parkinson’s disease with the combination of“Buyi Ganshen”and dopa preparation were more effective compared to dopa preparation alone.Conclusion:“Buyi Ganshen”combined with dopa preparation exists,in some degree,to enhance clinical safety and effectivene

关 键 词：Parkinson’s disease Buyi Ganshen Dopa preparation META-ANALYSIS 

分 类 号：R74[医药卫生—神经病学与精神病学]