芝麻酚的合成工艺改进  

Improved Synthesis of Sesamol

作　　者：张宁 杨利 付丙月 孔祥雨 郭亚芸 刘文涛 张宗磊 ZHANG Ning;YANG Li;FU Bing-yue;KONG Xiang-yu;GUO Ya-yun;LIU Wen-tao;ZHANG Zong-lei(Key Lab for Chemical Drug Research of Shandong Province,Shandong Academy of Pharmaceutical Science,Jinan 250101,China;Shandong Academy of Grape,Jinan 250100,China)

机构地区：[1]山东省药学科学院山东省化学药物重点实验室,山东济南250101 [2]山东省葡萄研究院,山东济南250100

出　　处：《精细化工中间体》2020年第4期21-23,共3页Fine Chemical Intermediates

基　　金：山东省重大科技创新工程项目(2019JZZY010520)。

摘　　要：以胡椒环为原料,经傅克酰基化、Bayer-Villiger氧化、水解3步反应合成了芝麻酚,总收率77.6%,产品纯度99.0%以上。其结构经熔点、核磁共振氢谱(1H NMR)确证。该方法工艺操作简单、反应温和,适合工业化生产。Sesamol was synthesized from a three-step reaction including Friedel-Crafts reaction,Bayer-Villiger oxidation and hydroilsis using 1,3-benzodioxole as the starting materials in an overall yield of 77.6%and a purity of99.0%.The structure of the target compound was confirmed by melting point and1 H NMR.This improved process is simple,costs reducing,mild reaction condition and suitable for industrial production.

关 键 词：胡椒环 芝麻酚 FRIEDEL-CRAFTS Bayer-Villiger 

分 类 号：TQ243[化学工程—有机化工]