松香基Schiff碱杂环衍生物的合成及抑菌活性  

Synthesis and Antibacterial Activity of Rosin-based Heterocyclic Schiff Bases

作　　者：伍勇 黄春花[1] 徐静 WU Yong;HUANG Chun-hua;XU Jing(Department of Pharmacy,Sichuan Vocational College of Health and Rehabilitation,Zigong 643000,China;College of Landscape Architecture and Art,Jiangxi Agriculture University,Nanchang 330045,China)

机构地区：[1]四川卫生康复职业学院药学系,四川自贡643000 [2]江西农业大学园林与艺术学院,江西南昌330045

出　　处：《精细化工中间体》2020年第4期30-33,40,共5页Fine Chemical Intermediates

基　　金：国家林业局林业公益性行业科研专项(200704008);自贡市重点科技计划资助项目(2018CZ30)。

摘　　要：脱氢枞胺及降解脱氢枞胺分别与杂环甲醛在乙醇溶剂中缩合合成了6个松香基Schiff碱杂环衍生物(a1/a2、b1/b2、c1/c2),并对产物结构进行了IR、1H NMR光谱表征确证。通过体外最低抑菌活性测试,结果表明,化合物c1和c2对金黄色葡萄球菌(Staphylococcus aureus)、表皮葡萄球菌(Staphylococcus epidermidis)、绿脓杆菌(Pseudomonas aeruginosa)和产气杆菌(Bacterium aerogenes)具有显著效果,其最低抑菌浓度(the Minimum Inhibitory Concentration)均为32μg·mL^-1。Using ethanol as solvent six rosin-based heterocyclic Schiff bases were synthesized from the condensation reaction between dehydroabietylamine or nor-dehydroabietylamine and heterocyclic formaldehyde.Their structures were confirmed by IR and 1H NMR spectroscopy.The minimum antibacterial activities of six compounds were tested by extracorporeal experiment.The results showed that compounds(c1 and c2)were relatively ideal and their least MICs of Staphylococcus aureus,Staphylococcus epidermidis,Pseudomonas aeruginosa,and Bacterium aerogenes was 32μg·mL^-1.

关 键 词：脱氢枞胺 降解脱氢枞胺 SCHIFF碱 合成 抑菌活性 

分 类 号：R977.4[医药卫生—药品]