Notch信号通路在骨髓间充质干细胞及骨代谢疾病中的功能研究进展  

Research progress in the function of Notch signaling pathway in bone marrow mesenchymal stem cells and bone metabolic diseases

作　　者：雷乐[1] 张玲莉 杨杰[1] LEI Le;ZHANG Lingli;YANG Jie(Shanghai University of Sport,Shanghai 200438,China;South China Normal University,Guangzhou 510631,China)

机构地区：[1]上海体育学院,上海200438 [2]华南师范大学,广东广州510631

出　　处：《中国骨质疏松杂志》2020年第9期1364-1369,共6页Chinese Journal of Osteoporosis

基　　金：2019年上海体育学院附属竞技体育学校教育教学课题中职内涵建设经费,上海市人类运动能力开发与保障重点实验室(上海体育学院11DZ2261100);中国博士后科学基金(2019M662962)。

摘　　要：骨髓间充质干细胞是存在于骨髓基质中的一种多能干细胞,具有多向分化的潜能,其天然再生能力对骨骼的生长代谢和骨转换起着至关重要的作用。Notch信号通路是一条在进化中高度保守的信号转导通路,与骨髓间充质干细胞的增殖、分化与凋亡密切相关,影响人体骨骼发育,也是多种骨代谢疾病的重要调节通路。以往对Notch信号通路的研究主要集中在神经干细胞,对骨髓间充质干细胞的研究较少。本文通过查阅文献,阐述不同的影响因素介导Notch信号通路对骨髓间充质干细胞分化的调节,并总结了Notch信号通路在骨代谢疾病如Alagille综合征、Adams Oliver综合征、脊椎肋骨发育不良、Hajdu-Cheney综合征、骨折愈合中的研究近况。Bone marrow mesenchymal stem cells(BMSCs)are pluripotent stem cells that are present in the bone marrow stroma and potential for multi-directional differentiation.Their natural regenerative capacity plays an important role in bone growth and metabolism and bone turnover.Notch signaling pathway is a highly conserved signal transduction pathway in evolution.It is related to the growth,differentiation,and apoptosis of bone marrow mesenchymal stem cells,affecting human bone development,and is also an important regulatory pathway for various bone metabolic diseases.Previous studies of the Notch signaling pathway are mainly focused on neural stem cells,and little is concerned on BMSCs.This paper describes the regulation of BMSCs by different factors through Notch signaling pathway by literature searching,and summaries the recent research of Notch signaling pathway in metabolic diseases such as Alagille syndrome,Adams Oliver syndrome,spinal rib dysplasia,Hajdu-Cheney syndrome,and fracture healing.

关 键 词：NOTCH信号通路 骨髓间充质干细胞 骨向分化 

分 类 号：R363[医药卫生—病理学]