Macrophage-NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes  

作　　者：Hong-Bin Lin Guan-Shan Wei Feng-Xian Li Wen-Jing Guo Pu Hong Ya-Qian Weng Qian-Qian Zhang Shi-Yuan Xu Wen-Bin Liang Zhi-Jian You Hong-Fei Zhang 

机构地区：[1]Department of Anesthesiology,Zhujiang Hospital of Southern Medical University,Guangzhou 510220,China [2]Department of Anesthesiology,Shenzhen SAMII Medical Center,Shenzhen 518118,China [3]Department of Anesthesiology,The Second Affiliated Hospital,Shantou University Medical College,Shantou 515041,China [4]University of Ottawa Heart Institute and Department of Cellular and Molecular Medicine,University of Ottawa,Ontario,K1N,Canada

出　　处：《Neuroscience Bulletin》2020年第9期1035-1045,共11页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (81771232 and 81974192);the Natural Science Foundation of Guangdong Province,China (2019A1515010654)。

摘　　要：Ischemic stroke is one of the leading causes of death worldwide.In the post-stroke stage,cardiac dysfunction is common and is known as the brain-heart interaction.Diabetes mellitus worsens the post-stroke outcome.Stroke-induced systemic inflammation is the major causative factor for the sequential complications,but the mechanism underlying the brain-heart interaction in diabetes has not been clarified.The NLRP3(NLR pyrin domain-containing 3) inflammasome,an important component of the inflammation after stroke,is mainly activated in M1-polarized macrophages.In this study,we found that the cardiac dysfunction induced by ischemic stroke is more severe in a mouse model of type 2 diabetes.Meanwhile,M1-polarized macrophage infiltration and NLRP3 inflammasome activation increased in the cardiac ventricle after diabetic stroke.Importantly,the NLRP3 inflammasome inhibitor CY-09 restored cardiac function,indicating that the Ml-polarized macrophage-NLRP3 inflammasome activation is a pathway underlying the brain-heart interaction after diabetic stroke.

关 键 词：Ischemic stroke Diabetes mellitus Cardiac dysfunction NLRP3 inflammasome MACROPHAGE 

分 类 号：R587.1[医药卫生—内分泌] R-332[医药卫生—内科学] R743.3[医药卫生—临床医学]