慢性酒精中毒性脑病诊治研究进展  

Research Progress on the Diagnosis and Treatment of Chronic Alcoholic Encephalopathy

作　　者：程雅莉 杨军[1] 曹笃[1] 李航 郁斌[1] CHENG Yali;YANG Jun;CAO Du;LI Hang;YU Bin(The First Afiliated Hospital of Chonging Medical University,Chongqing,China 400016)

机构地区：[1]重庆医科大学附属第一医院,重庆400016

出　　处：《中国药业》2020年第19期5-9,共5页China Pharmaceuticals

基　　金：重庆市社会事业与民生保障科技项目[cstc2017shmsA130111]。

摘　　要：慢性酒精中毒性脑病(CAE)是因酗酒引起硫胺素缺乏所致的神经系统慢性疾病,其发病机制与星形胶质细胞肿胀、线粒体功能受损、氧化应激增加、谷氨酸兴奋性毒性损伤等有关。该病临床表现多样,且易与其他神经系统疾病症状重合,临床难以鉴别。目前,CAE尚缺乏特异的检验检查方法,主要依靠饮酒史及临床表现来诊断,头颅核磁共振成像技术的发展也为疾病的早期诊断提供了帮助。硫胺素替代疗法是治疗CAE的关键,也是治疗进展的新方向。Chronic alcoholic encephalopathy( CAE) is a chronic neurological disorder caused by thiamine deficiency due to alcoholism.Its pathogenesis is associated with astrocytes swelling,impaired mitochondrial function,increased oxidative stress,glutamate excitotoxic injury and other related.The disease has diverse clinical manifestations and is easy to overlap with symptoms of other neurological diseases,which is difficult to identify clinically.At present,the diagnosis of the disease lacks specific test methods and mainly relies on the drinking history and clinical manifestations,and the development of head magnetic resonance imaging( MRI) has certain significance for early diagnosis.Thiamin replacement therapy is the core of CAE treatment,and some studies in recent years have brought new directions to treatment.

关 键 词：慢性酒精中毒性脑病 发病机制 头颅核磁共振成像 硫胺素 

分 类 号：R971[医药卫生—药品]