Modeling the Long-term Antibody Response and Duration of Immune Protection Induced by an Inactivated,Preservative-free Hepatitis A Vaccine(Healive)in Children  

作　　者：YU Yong Pei CHEN Jiang Ting JIANG Zhi Wei WANG Ling YU Cheng Kai YAN Xiao Yan YAO Chen XIA Jie Lai 

机构地区：[1]College of Military Preventive Medicine,the Fourth Military Medical University,Xi'an 710032,Shaanxi,China [2]Peking University^Clinical Research Institute,Peking University Health Science Center,Beijing 100191,China [3]Sinovac Biotech,Beijing 100089,China [4]Beijing Keytech Statistical Consulting,Beijing 100020,China

出　　处：《Biomedical and Environmental Sciences》2020年第7期484-492,共9页生物医学与环境科学（英文版）

基　　金：sub-project of National Major Scientific and Technological Special Project of China for‘Significant New Drugs Development’[2015ZX09501008-004]。

摘　　要：Objective Long-term seroprotection via the hepatitis A vaccine is essential for the prevention of disease from the hepatitis A virus(HAV).Due to documented difficulties during decade-long follow-ups after receiving vaccines,statistical-modeling approaches have been applied to predict the duration of immune protection.Methods Based on five-year follow-up data from a randomized positive-controlled trial among Chinese children(1–8 years old)following a 0,6 months vaccination schedule,a power-law model accounting for the kinetics of B-cell turnover,as well as a modified power-law model considering a memory-B-cell subpopulation,were fitted to predict the long-term immune responses induced by HAV vaccination(Healive or Havrix).Anti-HAV levels of each individual and seroconversion rates up to 30 years after vaccination were predicted.Results A total of 375 participants who completed the two-dose vaccination were included in the analysis.Both models predicted that,over a life-long period,participants vaccinated with Healive would have close but slightly higher antibody titers than those of participants vaccinated with Havrix.Additionally,consistent with previous studies,more than 90%of participants were predicted to maintain seroconversion for at least 30 years.Moreover,the modified power-law model predicted that the antibody titers would reach a plateau level after nearly 15 years post-vaccination.Conclusions Based on the results of our modeling,Healive may adequately induce long-term immune responses following a 0,6 months vaccination schedule in children via induction of memory B cells to provide stable and durable immune protection.

关 键 词：Hepatitis A Inactivated hepatitis A vaccine MODELING Antibody persistence Long-term follow-up 

分 类 号：R512.61[医药卫生—内科学] R186[医药卫生—临床医学]