基于中医传承辅助系统分析中医药治疗肝脾不调证溃疡性结肠炎的用药规律  

Analysis of prescription rules in treating ulcerative colitis with liver-spleen disorder syndrome based on traditional Chinese medicine inheritance support system

作　　者：李鹤 谢亚娟 厉启芳[2] 齐硕 刘善军[2] 孙冰 郑桂芝 孙闵 于斌 Li He;Xie Yajuan;Li Qifang;Qi Shuo;Liu Shanjun;Sun Bing;Zheng Guizhi;Sun Min;Yu Bin(School of Integrated Traditional Chinese and Western Medicine,Jining Medical University,Jining 272067,China;Department of Traditional Chinese Medicine,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院中西医结合学院,272067 [2]济宁医学院附属医院中医科,272029

出　　处：《中国医药》2020年第10期1580-1584,共5页China Medicine

基　　金：国家自然科学基金(81603509);山东省自然科学基金(ZR2014HQ051);山东省中医药科技发展计划(2015-241)。

摘　　要：目的利用中医传承辅助系统平台,分析期刊文献中采用中医药治疗肝脾不调证溃疡性结肠炎的用药组方规律。方法筛选1990年1月至2017年11月发表在中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(维普)、万方数据库中关于中医药治疗肝脾不调证溃疡性结肠炎的文献,数据录入中医传承辅助平台,采用软件的数据分析模块,分析肝脾不调证溃疡性结肠炎的中医药用药规律,分析用药的四气、五味、归经、药物使用频次、组方规律和潜在的新方组合。结果纳入文献64篇,涉及中药94味。药物以温性(271次)、寒性(183次)、平性(121次)为多,苦味(353次)、甘味(285次)、辛味(260次)为主,主要归脾经(480次)、胃经(258次)、肝经(258次),用药频次最多的6味药是白芍(60次)、白术(58次)、陈皮(49次)、防风(47次)、甘草(43次)和柴胡(39次),药物配伍前6位组合为白术-白芍、陈皮-白芍、陈皮-白术、陈皮-白术-白芍、白术-防风、白芍-防风,共挖掘出核心药物组合16个,新方组合2个。结论文献数据的用药规律结果显示,本病本证的用药以疏肝理气、健脾化湿、缓急止痛药物为主,药物选择以归脾、胃、肝经药物为主,进而为临床治疗肝脾不调证用药提供思路。Objective To analyze the rules of traditional Chinese medicine(TCM)prescription in treatment of ulcerative colitis with liver-spleen disorder syndrome using the TCM inheritance support system(TCMISS).Methods Literatures of ulcerative colitis with liver-spleen disorder treated with TCM were screened in China Biology Medicine disc,China National Knowledge Infrastructure,VIP Chinese Journal Full-text Database and Wanfang Data from January 1990 to November 2017.Valid data were retrieved and logged into TCMISS to analyze the frequencies regarding four properties,five tastes,meridian tropism,common herbs,common prescriptions and potential new combinations.Results A total of 64 literatures involving 94 herbs were anlyzed.Properties of most herbs were warm(271),cold(183)or mild(121).Tastes of most herbs were bitter(353),sweet(285)or spicy(260).The herbs mainly worked along the spleen(480),stomach(258)and liver(258)meridians.The top6 herbs were Radix paeoniae alba(60),Rhizoma atractylodis macrocephalae(58),Pericarpium citri reticulatae(49),Radix sileris(47),Licorice(43)and Bupleurum(39).The top 6 prescriptions were"Rhizoma atractylodis macrocephalae and Radix paeoniae alba","Pericarpium citri reticulatae and Radix paeoniae alba","Pericarpium citri reticulatae and Rhizoma atractylodis macrocephalae","Pericarpium citri reticulatae and Rhizoma atractylodis macrocephalae and Radix paeoniae alba","Rhizoma atractylodis macrocephalae and Radix sileris","Radix paeoniae alba and Radix sileris".Sixteen core herb combinations and 2 new combinations were recommended.Conclusions Treatment of ulcerative colitis with liver-spleen disorder syndrome mainly focus on soothing liver and regulating Qi,invigorating spleen and resolving dampness,relieving spasm and pain.Chinese herbs mainly work on the spleen,stomach and liver meridians.

关 键 词：溃疡性结肠炎 肝郁脾虚 组方规律 辨证 

分 类 号：R574.62[医药卫生—消化系统]