结直肠癌患者HER-2表达与临床病理特征及预后的关系  

Expression of HER-2 in colorectal cancerand its relationship with clinicopathological characteristics and prognosis of patients

作　　者：潘坚慧 奕天飞 杭晨 余永明[3] 卿艳平[1] 严志龙[4] 施益九[4] PAN Jianhui;YI Tianfei;HANG Chen;YU Yongming;QING Yanping;YAN Zhilong;SHI Yijiu(Department of Anorectal Surgery,the Affiliated Hospital of Medical School of Ningbo University,Ningbo 315200,China)

机构地区：[1]宁波大学医学院附属医院肛肠科,315200 [2]宁波大学医学院 [3]宁波市第二医院肛肠科 [4]宁波市第一医院胃肠外科

出　　处：《浙江医学》2020年第19期2084-2088,I0005,共6页Zhejiang Medical Journal

基　　金：宁波市自然基金项目(2016A610157);浙江省中医药科技计划项目(2018ZA109)。

摘　　要：目的探讨结直肠癌患者人表皮生长因子受体2(HER-2)表达与临床病理特征及预后的关系。方法选取2014年1月至2019年6月收治的3818例结直肠癌为研究对象,其中宁波市第一医院1675例,宁波市第二医院1409例,宁波大学医学院附属医院734例;截至2019年12月31日,246例患者完成术后随访。采用免疫组化染色法测定HER-2表达情况,比较不同临床病理特征的结直肠癌患者HER-2表达阳性率,比较不同HER-2表达水平的结直肠癌患者生存率。结果3818例结直肠癌患者HER-2(-)、(+)、(++)、(+++)分别为3017、684、75、42例,HER-2表达阳性率为21.0%。不同性别、TNM分期、分化程度、淋巴结转移、有无远处转移及转移器官情况的结直肠癌患者HER-2表达阳性率比较,差异均有统计学意义(均P<0.05);不同年龄、肿瘤大小、类型、位置、解剖学部位、、浸润深度以及无神经及脉管侵犯的结直肠癌患者HER-2表达阳性率比较,差异均无统计学意义(均P>0.05)。246例完成随访的结直肠癌患者中,HER-2(-)、(+)、(++)、(+++)患者5年生存率分别为84.9%、79.0%、78.9%、73.7%,差异无统计学意义(P>0.05)。结论结直肠癌患者HER-2表达与其性别、TNM分期、分化程度、淋巴结转移、有无远处转移及转移器官情况等临床病理特征有一定的联系,但与预后无关,对病情评估有一定的指导意义。Objective To investigate the the expression of human epidermal growth factor receptor 2(HER-2)in colorectal cancer and its relationship with clinicopathological characteristics and prognosis of patients.Methods A total of 3818 patients with colorectal cancer admitted in Ningbo First Hospital(1675 cases),Ningbo Second Hospital(1409 cases)and Affiliated Hospital of Ningbo University Medical School(734 cases)from January 2014 to June 2019 were enrolled in the study.Immunohistochemical staining was used to determine the expression of HER-2,the relationship of HER-2 expression with clinicopathological characteristics and the survival rate of patients was analyzed.Results The cases with HER-2 expression(-),(+),(++),(+++)were 3017,684,75,42 respectively with an overall positive rate of 21.0%.HER-2 expression was associated with gender,TNM stage,degree of differentiation,lymph node metastasis,distant metastasis and organs of metastasis(P<0.05),while not associated with age,tumor size,tumor types,anatomical locations,depth of invasion,nerve and vascular invasion(P>0.05).Among the 246 patients with colorectal cancer who completed the follow-up,the 5-year survival rates of patients with HER-2(-),(+),(++),and(+++)were 84.9%,79.0%,78.9%and 73.7%,respectively(P>0.05).Conclusion The expression of HER-2 in patients with colorectal cancer is related to gender,TNM stage,degree of differentiation,lymph node metastasis,distant metastasisand organs of metastasis,but not related to the prognosis of patients.

关 键 词：结直肠癌 人表皮生长因子受体2 临床病理特征 预后 

分 类 号：R735.34[医药卫生—肿瘤]