分子影像探针早期诊断肝纤维化研究进展  

Research advances of molecular probes for early diagnosis of liver fibrosis

作　　者：王璐[1] 辛军[1] WANG Lu;XIN Jun(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院放射科,辽宁沈阳110004

出　　处：《中国医学影像技术》2020年第9期1400-1404,共5页Chinese Journal of Medical Imaging Technology

基　　金：辽宁省重点研发计划攻关项目(2017225030);沈阳市科学技术计划项目(18014423)。

摘　　要：肝纤维化早期具有可逆性及可治愈性,早期诊断肝纤维化及判断其程度具有重要意义。针对肝纤维化发生发展中异常表达分子构建的靶向探针能精准、无创地整合人体生理、病理代谢分子信息,有利于早期及特异性诊断纤维化。本文针对分子探针早期诊断肝纤维化研究进展进行综述。Early liver fibrosis is reversible and curable.Therefore,early diagnosis and staging of liver fibrosis are of great clinical significance.Targeting at the abnormal expression molecules in development of liver fibrosis,molecular probes are constructed as precise and non-invasive methods to integrate the information of human physiological and pathological metabolism,which is beneficial to early and specific diagnosis of fibrosis.The advances in molecular probes for early diagnosis and staging of liver fibrosis were reviewed in this article.

关 键 词：肝硬化 诊断显像 分子成像 分子探针技术 

分 类 号：R575.2[医药卫生—消化系统] R445[医药卫生—内科学]