Inflammatory niche:Mesenchymal stromal cell priming by soluble mediators  

作　　者：Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić-Đorđević Slavko Mojsilović Diana Bugarski 

机构地区：[1]Laboratory for Experimental Hematology and Stem Cells,Institute for Medical Research,University of Belgrade,Belgrade 11129,Serbia

出　　处：《World Journal of Stem Cells》2020年第9期922-937,共16页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by the Ministry of Education,Science and Technological Development,Republic of Serbia,No.451-03-68/2020-14/200015.

摘　　要：Mesenchymal stromal/stem cells(MSCs)are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell lineages.They play a critical role in tissue homeostasis and wound healing,as well as in regulating the inammatory microenvironment through interactions with immune cells.Hence,MSCs have garnered great attention as promising candidates for tissue regeneration and cell therapy.Because the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs,priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these cells.In this paper,we review how soluble mediators of the inflammatory niche(cytokines and alarmins)influence the regenerative and immunomodulatory capacity of MSCs,highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed MSCs.The data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.

关 键 词：Mesenchymal stem cells Pro-inflammatory cytokines ALARMINS PRIMING Boosting the therapeutic potential 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]