Senescent mesenchymal stem/stromal cells and restoring their cellular functions  

作　　者：Qing-Shu Meng Jing Liu Lu Wei Hui-Min Fan Xiao-Hui Zhou Xiao-Ting Liang 

机构地区：[1]Shanghai Heart Failure Research Center,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China [2]Research Center for Translational Medicine,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China [3]Institute of Integrated Traditional Chinese and Western Medicine for Cardiovascular Chronic Diseases,Tongji University School of Medicine,Shanghai 200120,China [4]Department of Heart Failure,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China [5]Institute for Regenerative Medicine,Shanghai East Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200120,China

出　　处：《World Journal of Stem Cells》2020年第9期966-985,共20页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by the National Natural Science Foundation of China,Nos.81500207,81670458,and 81470393;Shanghai Municipal Health and Family Planning Commission,No.ZY(2018-2020)-FWTX-2007;Shanghai Key Medical Discipline for Critical Care Medicine,No.2017zz02017;the National Key Research and Development Program of China,No.2017YFA0105600;Major Program of Development Fund for Shanghai Zhangjiang National Innovtaion Demonstration Zone,No.ZJ2018-ZD-004;the Science and Technology Commission of Shanghai Municipality,No.17431906600;and the Top-level Clinical Discipline Project of Shanghai Pudong,No.PWYgf2018-05.

摘　　要：Mesenchymal stem/stromal cells(MSCs)have various properties that make them promising candidates for stem cell-based therapies in clinical settings.These include self-renewal,multilineage differentiation,and immunoregulation.However,recent studies have confirmed that aging is a vital factor that limits their function and therapeutic properties as standardized clinical products.Understanding the features of senescence and exploration of cell rejuvenation methods are necessary to develop effective strategies that can overcome the shortage and instability of MSCs.This review will summarize the current knowledge on characteristics and functional changes of aged MSCs.Additionally,it will highlight cell rejuvenation strategies such as molecular regulation,noncoding RNA modifications,and microenvironment controls that may enhance the therapeutic potential of MSCs in clinical settings.

关 键 词：Mesenchymal stem cells SENESCENCE Features Function Rejuvenation strategy 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]