Mechanisms of repetitive transcranial magnetic stimulation for antidepression: Evidence from preclinical studies  

作　　者：Di Luan Ming-Ge Zhao Ya-Chen Shi Ling Li Yu-Jia Cao Hai-Xia Feng Zhi-Jun Zhang 

机构地区：[1]Department of Neurology,Affiliated Zhongda Hospital,Research Institution of Neuropsychiatry,School of Medicine,Southeast University,Nanjing 210009,Jiangsu Province,China [2]Department of Nursing,School of Medicine,Southeast University,Nanjing 210009,Jiangsu Province,China [3]Department of Psychology,Xinxiang Medical University,Xinxiang 453003,Henan Province,China [4]Mental Health Center,Zhejiang University School of Medicine,Hangzhou 310013,Zhejiang province,China

出　　处：《World Journal of Psychiatry》2020年第10期223-233,共11页世界精神病学杂志

基　　金：National Key R and D Program of China,No.2016YFC1306700;The Key Projects of National Natural Science Foundation of China,No.81830040;Science and Technology Program of Guangdong,China,No.2018B030334001;Program of Excellent Talents in Medical Science of Jiangsu Province,China,No.JCRCA2016006.

摘　　要：This review summarizes the anti-depressant mechanisms of repetitive transcranial magnetic stimulation in preclinical studies,including anti-inflammatory effects mediated by activation of nuclear factor-E2-related factor 2 signaling pathway,anti-oxidative stress effects,enhancement of synaptic plasticity and neurogenesis via activation of the endocannabinoid system and brain derived neurotrophic factor signaling pathway,increasing the content of monoamine neurotransmitters via inhibition of Sirtuin 1/monoamine oxidase A signaling pathway,and reducing the activity of the hypothalamic-pituitary-adrenocortical axis.We also discuss the shortcomings of transcranial magnetic stimulation in preclinical studies such as inaccurate positioning,shallow depth of stimulation,and difficulty in elucidating the neural circuit mechanism up-and down-stream of the stimulation target brain region.

关 键 词：Repetitive transcranial magnetic stimulation Anti-depressant mechanisms Nuclear factor-e2-related factor 2 Endocannabinoid system Monoamine oxidase Hypothalamic-pituitary-adrenocortical axis Brain derived neurotrophic factor 

分 类 号：R749.4[医药卫生—神经病学与精神病学]