Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update  

作　　者：Donald Turbiville Xuchen Zhang 

机构地区：[1]Department of Pathology,Yale University School of Medicine,New Haven,CT 06510,United States

出　　处：《World Journal of Gastroenterology》2020年第37期5597-5605,共9页世界胃肠病学杂志（英文版）

摘　　要：Calcifying fibrous tumor(CFT)is a rare mesenchymal lesion that has been documented throughout the gastrointestinal tract.Gastrointestinal CFTs may occur at virtually any age,with a predilection for adults and for females.They occur most commonly in the stomach and the small and large intestines.CFTs are most often found incidentally,cured by local resection,and have a low risk of recurrence.Histology shows three characteristic features:Spindle cell proliferations within a densely hyalinized stroma,scattered calcifications,and lymphoplasmacytic inflammation.CFTs are immunoreactive for CD34,vimentin and factor XIIIa,helping to distinguish them from other benign mesenchymal neoplasms.The differential diagnosis of CFTs includes sclerosing gastrointestinal stromal tumor,leiomyoma,schwannoma,solitary fibrous tumor,inflammatory myofibroblastic tumor,plexiform fibromyxoma,fibromatosis,sclerosing mesenteritis,and reactive nodular fibrous pseudotumor.The pathogenesis of CFTs remains unclear,but some have hypothesized that they may be linked to IgG4-related disease,inflammatory myofibroblastic lesions,hyaline vascular type Castleman disease,sclerosing angiomatoid nodular transformation of the spleen,or trauma.

关 键 词：Calcifying fibrous tumor Calcifying fibrous pseudotumor Gastrointestinal tract Mesenchymal lesion CALCIFICATION Pathology 

分 类 号：R735[医药卫生—肿瘤]