Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study  

作　　者：Eun Ae Kang Jaeyoung Chun Jee Hyun Kim Kyungdo Han Hosim Soh Seona Park Seung Wook Hong Jung Min Moon Jooyoung Lee Hyun Jung Lee Jun-Beom Park Jong Pil Im Joo Sung Kim 

机构地区：[1]Department of Internal Medicine and Institute of Gastroenterology,Yonsei University College of Medicine,Seoul 03722,South Korea [2]Department of Internal Medicine,Gangnam Severance Hospital,Yonsei University College of Medicine,Seoul 06229,South Korea [3]Department of Internal Medicine,Bundang CHA Medical Center,CHA University School of Medicine,Seoul 13496,South Korea [4]Department of Statistics and Actuarial Science,Soongsil University,Seoul 06978,South Korea [5]Department of Internal Medicine and Liver Research Institute,Seoul National University College of Medicine,Seoul 03080,South Korea [6]Department of Periodontics,the Catholic University of Korea College of Medicine,Seoul 06591,South Korea

出　　处：《World Journal of Gastroenterology》2020年第37期5661-5672,共12页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Periodontitis is a chronic inflammation of periodontal tissues.The effect of periodontitis on the development of inflammatory bowel disease(IBD)remains unclear.AIM To assessed the risk of IBD among patients with periodontitis,and the risk factors for IBD related to periodontitis.METHODS A nationwide population-based cohort study was performed using claims data from the Korean National Healthcare Insurance Service.In total,9950548 individuals aged≥20 years who underwent national health screening in 2009 were included.Newly diagnosed IBD[Crohn’s disease(CD),ulcerative colitis(UC)]using the International Classification of Disease 10th revision and rare intractable disease codes,was compared between the periodontitis and nonperiodontitis groups until 2017.RESULTS A total of 1092825 individuals(11.0%)had periodontitis.Periodontitis was significantly associated with older age,male gender,higher body mass index,quitting smoking,not drinking alcohol,and regular exercise.The mean age was 51.4±12.9 years in the periodontitis group and 46.6±14.2 years in the nonperiodontitis group(P<0.01),respectively.The mean body mass index was 23.9±3.1 and 23.7±3.2 in the periodontitis and non-periodontitis groups,respectively(P<0.01).Men were 604307(55.3%)and 4844383(54.7%)in the periodontitis and non-periodontitis groups,respectively.The mean follow-up duration was 7.26 years.Individuals with periodontitis had a significantly higher risk of UC than those without periodontitis[adjusted hazard ratio:1.091;95%confidence interval(CI):1.008-1.182],but not CD(adjusted hazard ratio:0.879;95%confidence interval:0.731-1.057).The risks for UC were significant in the subgroups of age≥65 years,male gender,alcohol drinker,current smoker,and reduced physical activity.Current smokers aged≥65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers aged≥65 years without periodontitis.CONCLUSION Periodontitis was significantly associated with the risk of developing UC,but not CD,particularly in current

关 键 词：Inflammatory bowel disease PERIODONTITIS SMOKING Ulcerative colitis Crohn’s disease 

分 类 号：R781.42[医药卫生—口腔医学] R574.62[医药卫生—临床医学]