去整合素-金属蛋白酶17在消化系统恶性肿瘤中的研究现状  

Role of a disintegrin and metalloproteinase 17 in malignant tumors of the digestive system

作　　者：徐榕 康海锋[1] 刘宏斌[2] 钱俊波[1] Rong Xu;Hai-Feng Kang;Hong-Bin Liu;Jun-Bo Qian(Department of Gastroenterology and Hepatology,the Second Affiliated Hospital of Nantong University,Nantong 226000,Jiangsu Province,China;Department of Pathology,The Second Affiliated Hospital of Nantong University,Nantong 226000,Jiangsu Province,China)

机构地区：[1]南通大学第二附属医院消化内科,江苏省南通市226000 [2]南通大学第二附属医院病理科,江苏省南通市226000

出　　处：《世界华人消化杂志》2020年第19期986-991,共6页World Chinese Journal of Digestology

基　　金：南通市卫生和计划生育委员会科研课题专项,No.MB2019004。

摘　　要：去整合素-金属蛋白酶17(a disintegrin and metalloproteinase 17,ADAM17)即肿瘤坏死因子α转换酶,在哺乳动物细胞中广泛分布,与细胞黏附、细胞迁移、白细胞募集、蛋白水解等功能密切相关.ADAM17在恶性肿瘤发生发展中起重要作用,一方面通过介导膜蛋白脱落激活信号通路,参与细胞增殖、血管生成等;另一方面,通过降解细胞基底膜和细胞外基质,在肿瘤的侵袭和转移中发挥重要作用.因此,ADAM17可能作为肿瘤治疗的潜在靶点,本文就ADAM17在消化系统恶性肿瘤中的相关研究进行综述.A disintegrin and metalloproteinase 17(ADAM17),also known as tumor necrosis factor-alpha converting enzyme,is widely distributed in mammalian cells and closely related to cell adhesion,migration,leukocyte recruitment,proteolysis,and other functions.ADAM17 plays an important role in the development of malignant tumors.On the one hand,it activates signaling pathways by mediating membrane protein shedding to participate in cell proliferation and angiogenesis.On the other hand,it plays an important role in tumor invasion and metastasis by degrading the cell basement membrane and extracellular matrix.Therefore,ADAM17 may be used as a potential target for tumor therapy.This article reviews the role of ADAM17 in malignant tumors of the digestive system.

关 键 词：去整合素-金属蛋白酶17 肿瘤坏死因子α转换酶 消化系统 恶性肿瘤 

分 类 号：R735[医药卫生—肿瘤]