Clinical features of cardiac nodularity-like appearance induced by Helicobacter pylori infection  

作　　者：Toshihiro Nishizawa Kosuke Sakitani Hidekazu Suzuki Shuntaro Yoshida Yosuke Kataoka Yousuke Nakai Hirotoshi Ebinuma Takanori Kanai Osamu Toyoshima Kazuhiko Koike 

机构地区：[1]Department of Gastroenterology,Toyoshima Endoscopy Clinic,Tokyo 1570066,Japan [2]Department of Gastroenterology,Narita Hospital,International University of Health and Welfare,Chiba 2868520,Japan [3]Department of Gastroenterology,Sakitani Endoscopy Clinic,Chiba 2740825,Japan [4]Department of Internal Medicine,Tokai University School of Medicine,Kanagawa 2591193,Japan [5]Department of Gastroenterology,Graduate School of Medicine,The University of Tokyo,Tokyo 1138655,Japan [6]Department of Internal Medicine,Keio University School of Medicine,Tokyo 1608582,Japan

出　　处：《World Journal of Gastroenterology》2020年第35期5354-5361,共8页世界胃肠病学杂志（英文版）

摘　　要：We have previously reported that Helicobacter pylori(H.pylori)-associated nodular gastritis could occur in both the antrum and the cardia.Cardiac nodularity-like appearance(hereafter,called as cardiac nodularity)had a high predictive accuracy for the diagnosis of H.pylori infection.In the previous study,we included only the patients who were evaluated for H.pylori infection for the
rst time,and excluded patients with a history of eradication.Therefore,the prevalence and clinical features of cardiac nodularity remains unknown.AIM To perform this cross-sectional study to explore the characteristics of cardiac nodularity.METHODS Consecutive patients who underwent esophagogastroduodenoscopy betweenMay,2017 and August,2019 in the Toyoshima Endoscopy Clinic were enrolled in this study.We included H.pylori-negative,H.pylori-positive,and H.pylorieradicated patients,and excluded patients with unclear H.pylori status and eradication failure.H.pylori infection was diagnosed according to serum anti-H.pylori antibody and the urea breath test or histology.Cardiac nodularity was defined as a miliary nodular appearance or the presence of scattered whitish circular small colorations within 2 cm of the esophagogastric junction.Nodularity was visualized as whitish in the narrow-band imaging mode.We collected data on the patients’baseline characteristics.RESULTS A total of 1078 patients were finally included.Among H.pylori-negative patients,cardiac nodularity and antral nodularity were recognized in 0.14%each.Among H.pylori-positive patients,cardiac nodularity and antral nodularity were recognized in 54.5%and 29.5%,respectively.Among H.pylori-eradicated patients,cardiac nodularity and antral nodularity were recognized in 4.5%and 0.6%,respectively.The frequency of cardiac nodularity was significantly higher than that of antral nodularity in H.pylori-positive and-eradicated patients.The frequencies of cardiac nodularity and antral nodularity in H.pylori-eradicated patients were significantly lower than those in H.pylori-positive pat

关 键 词：CARDIA NODULARITY Helicobacter pylori Diagnosis GASTRITIS 

分 类 号：R573[医药卫生—消化系统] R541[医药卫生—内科学]