SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma mimicking solid pseudopapillary neoplasm: A case report and review of the literature  

作　　者：Yinan Hua Piyush Soni Douglas Larsen Riyam Zreik Bing Leng Debby Rampisela 

机构地区：[1]Department of Pathology,Baylor Scott&White Health,Texas A&M University College of Medicine,Temple,TX 76508,United States

出　　处：《World Journal of Gastroenterology》2020年第36期5520-5526,共7页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a very aggressive tumor that is rarely reported in the literature.The tumor has a predominant rhabdoid cell component and different patterns of growth have been reported.CASE SUMMARY A 59-year-old woman presented with diffuse abdominal pain,increasing in severity and accompanied by weight loss,nausea,and vomiting.Imaging showed a pancreatic head mass.Fine needle aspiration demonstrated atypical epithelioid cells with a pseudopapillary growth pattern suggestive of solid pseudopapillary neoplasm.The excised neoplasm showed monotonous epithelioid and focally spindle cells with pseudopapillary structures,rhabdoid features,and loss of SMARCB1 protein expression with wild-type KRAS,consistent with a SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma.The patient’s condition deteriorated rapidly following surgery and she expired 3 mo post operation.CONCLUSION In this article,we report the first case of SMARCB1/INI1-deficient undifferentiated pancreatic rhabdoid carcinoma mimicking solid pseudopapillary neoplasm.

关 键 词：Pancreatic undifferentiated rhabdoid carcinoma Solid pseudopapillary neoplasm SMARCB1/INI1 KRAS Case report 

分 类 号：R735.9[医药卫生—肿瘤]