小剂量丙戊酸镁联合抗精神病药物治疗精神分裂伴攻击行为患者的临床效果  

Clinical Effect of Low-dose Magnesium Valproate Combined with Antipsychotics in the Treatment of Schizophrenia with Aggressive Behavior

作　　者：鄂娜 E Na(Jinzhou Kangning Hospital,Jinzhou 121000,China)

机构地区：[1]锦州市康宁医院,辽宁锦州121000

出　　处：《中国医药指南》2020年第26期109-110,共2页Guide of China Medicine

摘　　要：目的探讨小剂量丙戊酸镁联合抗精神病药物治疗精神分裂伴攻击行为患者的临床效果。方法收集2018年6月至2019年6月锦州市康宁医院收治的140例精神分裂伴随攻击行为的患者为研究对象,随机分成对照组和研究组,每组70例。对照组单独用抗精神病药物治疗,研究组在对照组基础上给予小剂量丙戊酸镁治疗,比较两组患者的疗效。结果研究组PANSS、MOAS评分低于对照组,差异均有统计学意义(P <0.05)。研究组不良反应总发生率为2.86%,低于对照组的4.29%,但差异无统计学意义(P> 0.05)。结论小剂量丙戊酸镁联合抗精神病药物治疗精神分裂伴攻击行为患者的效果较好,能有效减轻患者的症状和攻击行为,且不良反应发生率较低。Objective To investigate the clinical eff ect of low-dose magnesium valproate combined with antipsychotics in the treatment of schizophrenia with aggressive behavior.Methods A total of 140 schizophrenic patients with aggressive behavior admitted to Jinzhou Kangning Hospital from June 2018 to June 2019 were selected and randomly divided into control group and study group,with 70 cases in each group.The control group was treated with antipsychotics alone,and the study group was given low-dose magnesium valproate on the basis of the control group.The efficacy of the two groups was compared.Results The scores of PANSS and moas in the study group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the study group was 2.86%,lower than 4.29%in the control group,but the diff erence was not statistically signifi cant(P>0.05).Conclusion Small dose of magnesium valproate combined with antipsychotics in the treatment of schizophrenia with aggressive behavior has good eff ect,can eff ectively reduce the symptoms and aggressive behavior of patients,and the incidence of adverse reactions is low.

关 键 词：精神分裂 抗精神病药物 丙戊酸镁 喹硫平 攻击行为 

分 类 号：R749.3[医药卫生—神经病学与精神病学]