四溴联苯醚对雄性小鼠的急性毒性效应  

Acute Toxic Effects of BDE-47 on Male Mice

作　　者：庄娟[1,2,3] 张佳琪[1,2,3] 汤潇 李梦秋 徐建明 郑元林 ZHUANG Juan;ZHANG Jia-qi;TANG Xiao;LI Meng-qiu;XU Jian-ming;Zheng Yuan-lin(School of Life Science,Huaiyin Normal University,Huaian Jiangsu 223300,China;Collaborative Innovation Center of Regional Modern Agriculture&Environmental Protection,Huaiyin Normal University,Huaian Jiangsu 223300,China;Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake,Huaiyin Normal University,Huaian Jiangsu 223300,China;Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province,College of Health Sciences,Jiangsu Normal University,Xuzhou Jiangsu 221116,China)

机构地区：[1]淮阴师范学院生命科学学院,江苏淮安223300 [2]淮阴师范学院江苏省高校区域现代农业与环境保护协同创新中心,江苏淮安223300 [3]淮阴师范学院江苏省环洪泽湖生态农业生物技术重点实验室,江苏淮安223300 [4]江苏师范大学江苏省药用植物生物技术重点实验室,江苏徐州221116

出　　处：《淮阴师范学院学报（自然科学版）》2020年第3期223-226,共4页Journal of Huaiyin Teachers College;Natural Science Edition

基　　金：江苏省高校自然科学基金项目(18KJB330001)。

摘　　要：采用口腔灌胃染毒的方式,研究2,2′,4,4′-四溴联苯醚(BDE-47)对9周龄C57BL/6J雄性小鼠的急性毒效应.小鼠随机分为对照组和BDE-47处理组.对照组小鼠灌胃玉米油,BDE-47小鼠分别灌胃1150,1610,2254,3155和4418mg/kg剂量的BDE-47溶液.记录暴露0~24h的小鼠体质量.采用改进寇氏法检测BDE-47的半数致死剂量(LD50)和95%可信限.结果表明,暴露24h后,小鼠体质量随BDE-47剂量升高而降低;BDE-47对9周龄C57BL/6J雄性小鼠的LD50为2309mg/kg,LD50的95%可信限为1912~2788mg/kg;BDE-47急性毒性的靶器官主要为神经系统、消化系统、泌尿系统及眼.This study was aimed to explore the oral acute toxicity of 2,2,4,4-tetrabromodiphenyl ether(BDE-47)in male C57 BL/6 Jmice of 9 weeks old.Mice were orally gavaged with corn oil or different dose of BDE-47(1150,1610,2254,3155 or 4418 mg/kg body weight).Body weight after 0 and 24 hexposure was obtained.The median lethal dose(LD50 value)and 95%confidence interval were estimated by improved-Karber’s method.Our results showed that BDE-47 caused a dose-dependent reduction of body weight of mice.The LD50 value was 2308.9 mg/kg and 95%confidence interval were 1912.39~2787.66 mg/kg.The main target organs of BDE-47 were nervous system,gastrointestinal tract,urinary system and eyes.

关 键 词：BDE-47 小鼠 毒性作用 LD50 

分 类 号：X174[环境科学与工程—环境科学]