Nonasthmatic eosinophilic bronchitis in an ulcerative colitis patient-a putative adverse reaction to mesalazine:A case report and review of literature  

作　　者：Andrei Tudor Cernomaz Gabriela Bordeianu Cristina Terinte Cristina Maria Gavrilescu 

机构地区：[1]Department of Internal Medicine,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania [2]Department of Biochemistry,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania [3]Department of Pathology,Regional Oncology Institute,Iasi 700483,Romania

出　　处：《World Journal of Clinical Cases》2020年第18期4162-4168,共7页世界临床病例杂志

摘　　要：BACKGROUND Lung and airway involvement in inflammatory bowel disease are increasingly frequently reported either as an extraintestinal manifestation or as an adverse effect of therapy.CASE SUMMARY We report a case of a patient with ulcerative colitis controlled under mesalazine treatment who presented with chronic cough and hemoptysis.Chest computed tomography and bronchoscopy findings supported tracheal involvement in ulcerative colitis;pathology examination demonstrated an unusual eosinophilrich inflammatory pattern,and together with clinical data,a nonasthmatic eosinophilic bronchitis diagnosis was formulated.Full recovery was observed within days of mesalazine discontinuation.CONCLUSION Mesalazine-induced eosinophilic respiratory disorders have been previously reported,generally involving the lung parenchyma.To the best of our knowledge,this is the first report of mesalamine-induced eosinophilic involvement in the upper airway.

关 键 词：MESALAMINE Ulcerative colitis HEMOPTYSIS BRONCHITIS Drug-related side effects Case report 

分 类 号：R574.62[医药卫生—消化系统] R562.21[医药卫生—内科学]