PET/CT综合分析法联合密度比对NSCLC纵隔淋巴结转移的诊断价值分析  

Diagnostic value of PET/CT combined with density ratio in mediastinal lymph node metastasis of NSCLC

作　　者：何涛 李玉峰[2] 王欢[1] 孙江铭 姚玉唐 HE Tao;LI Yufeng;WANG Huan;SUN Jiangming;YAO Yutang(Department of Nuclear Medicine Discipline,Panzhihua City Central Hospital,Panzhihua 617067,P.R.China;Department of Ultrasound,Panzhihua City Central Hospital,Panzhihua,617067,P.R.China;Department of Nuclear Medicine Discipline,Sichuan Cancer Hospital,Chengdu 610042,P.R.China)

机构地区：[1]四川省攀枝花市中心医院核医学科,四川攀枝花617067 [2]四川省攀枝花市中心医院超声科,四川攀枝花617067 [3]四川省肿瘤医院核医学科,四川成都610042

出　　处：《医学影像学杂志》2020年第9期1640-1643,共4页Journal of Medical Imaging

摘　　要：目的探讨正电子发射体层显像(PET)/计算机体层成像(CT)综合分析法联合淋巴结与纵隔血池密度比对非小细胞肺癌(NSCLC)纵隔淋巴结转移的诊断价值。方法选取本院75例行PET/CT检查的NSCLC患者临床资料,记录患者病灶标准化最大摄取值(SUV max)和淋巴结SUV max、淋巴结短径、纵隔血池CT密度值等情况,并计算淋巴结与纵隔血池密度的比值。以术后病理结果为金标准,通过绘制受试者工作特征(ROC)曲线评估PET/CT综合分析法联合密度比对诊断患者纵隔淋巴结转移的预测价值。结果75例患者中,共检出淋巴结377枚,其中良性淋巴结321枚,纵隔淋巴结转移56枚。相比良性淋巴结者,纵隔淋巴结转移者淋巴结短径、病灶SUV max、淋巴结SUV max均明显升高,淋巴结与纵隔血池密度比明显下降(P<0.05)。ROC曲线分析结果发现,PET/CT综合分析法联合淋巴结与纵隔血池密度比对诊断NSCLC患者纵隔淋巴结转移的灵敏度、特异度及准确性分别为92.86%、85.98%、87.00%,明显高于二者单一诊断的效能。结论PET/CT综合分析法联合淋巴结与纵隔血池密度比对NSCLC患者纵隔淋巴结转移的诊断具有较高的评估价值。Objective To analyze the diagnostic value of PET/CT combined with the density ratio of lymph nodes to mediastinal blood pool in non-small cell lung cancer(NSCLC).Methods A retrospective study was conducted to collect the clinical data of 75 NSCLC patients who underwent PET/CT from December 2017 to June 2019 in our hospital.We recorded the maximum standardized uptake value(SUV max)of lesions and lymph nodes,short diameter of lymph nodes,CT density value of mediastinal blood pool,and calculated the ratio of lymph nodes to mediastinal blood pool density.The prediction value of PET/CT combined with density ratio in the diagnosis of mediastinal lymph node metastasis was evaluated by drawing receiver operating characteristic(ROC)curve.Results 377 lymph nodes were detected in 75 patients,including 321 benign lymph nodes and 56 mediastinal lymph nodes.Compared with benign lymph nodes,the short diameter of lymph nodes,SUV max of focus and SUVmax lymph nodes in mediastinal lymph node metastasis were significantly higher,and the density ratio of lymph nodes to mediastinal blood pool was significantly lower(P<0.05).The results of ROC curve analysis showed that the sensitivity,specificity and accuracy of PET/CT combined with the density ratio of lymph nodes and mediastinal blood pool were 92.86%,85.98%and 87.00%,respectively,which were significantly higher than the single diagnosis of NSCLC.Conclusion PET/CT combined with the density of lymph nodes and mediastinal blood pool has a higher value in the diagnosis of mediastinal lymph node metastasis in NSCLC.

关 键 词：非小细胞肺癌 正电子发射体层显像/计算机体层成像 密度比 纵隔淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤] R817.4[医药卫生—临床医学]