老年性自身免疫性肝炎的构成比及临床特征分析  

Analysis of constituent ratio and clinical characteristics in Senile autoimmune hepatitis

作　　者：吴玲玲 陈坚[1] 胡丽娟[1] 王君君[1] 王瑜敏[1] WU Ling-ling;CHEN Jian;HU Li-juan;WANG Jun-jun;WANG Yu-min(Clinical Laboratory,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州医科大学附属第一医院医学检验中心,浙江温州325000

出　　处：《中国卫生检验杂志》2020年第17期2049-2051,2055,共4页Chinese Journal of Health Laboratory Technology

基　　金：国家自然科学基金(81401736)。

摘　　要：目的探讨老年性自身免疫性肝炎(AIH)构成比变化及临床特征与青壮年患者差异。方法回顾性收集2012年1月-2016年12月温州医科大学附属第一医院初诊住院AIH患者资料,本研究共纳入了213例患者,男、女分别有48例和165例。将患者分为2组:老年组(121例)和青壮年组(92例)。评估分析AIH患者的构成比、实验室指标和病理等资料。结果患者平均发病年龄为(59.9±14.7)岁,男、女比例为1∶3.44,新增老年患者占总患者的56.8%,5年来老年患者构成比分别为15.7%、19.0%、20.7%、21.5%和23.1%,呈逐渐增加趋势。其中老年组的自身免疫合并症发生率、肝炎活动评分和白蛋白浓度低于青壮年组(P<0.05);Ig G浓度和抗核抗体(≥1∶100)阳性率高于青壮年组(P<0.05)。结论老年性AIH患者的构成比在逐年增加,老年性AIH患者的临床特征与免疫衰老有关。Objective The purpose of this study was to investigate constituent ratio changes of senile autoimmune hepatitis(AIH)and difference of clinical characteristics between the elderly and adults.Methods Data of AIH patients admitted to the First Affiliated Hospital of Wenzhou Medical University from January 2012 to December 2016 were collected retrospectively.A total of 213 patients were included in this study,including 48 male and 165 female patients,respectively.The patients were divided into two groups:the elderly group(121 cases)and the young adult group(92 cases).The composition ratio,laboratory indicators and pathological data of AIH patients were evaluated and analyzed.Results The average age of onset was 59.9±14.7 years old,the ratio of male to female was 1∶3.44,and new elderly patients accounted for 56.8%of total patients.In the past five years,the constituent ratio of the elderly patients was 15.7%,19.0%,20.7%,21.5%and 23.1%,respectively,showing a gradually increasing trend.The autoimmune comorbidities,hepatitis activity score,and the concentration of albumin in the elderly group were lower than those in the adult group(P<0.05).The elderly cohort had significantly higher levels of serum Ig G and antinuclear antibody(≥1∶100)positive rate,lesser hepatitis activity scores,and incidence rate of autoimmune comorbidities(P<0.05).Conclusion The proportion of elderly patients with AIH is steadily increasing.The clinical characteristics of elderly patients with AIH are associated with immunosenescence.

关 键 词：老年 自身免疫性肝炎 构成比 临床特征 

分 类 号：R575.1[医药卫生—消化系统]