^125I粒子联合胆道支架治疗恶性梗阻性黄疸的研究进展  

Research Progress of^125I Seeds Combined with Biliary Stent in the Treatment of Malignant Obstructive Jaundice

作　　者：吕诗剑 赖建平 Lv Shijian;Lai Jianping(Department of Nuclear Medicine,the People s Hospital of Three Gorges University,the Fit Peoplee Hospital of Yichang,Yichang,Hubei 443000)

机构地区：[1]三峡大学人民医院·宜昌市第一人民医院核医学科,湖北宜昌443000

出　　处：《现代医用影像学》2020年第9期1656-1659,共4页Modern Medical Imageology

摘　　要：恶性梗阻性黄疸是胆管癌、胰腺癌及壶腹部恶性肿瘤侵及胆道系统而引起的胆汁排泄受阻,发病隐匿,预后较差,大多数病人确诊时已经失去手术机会。胆道支架可以迅速缓解黄疸症状,已经成为恶性梗阻性黄疸的首选姑息治疗方法。但普通胆道支架并没有杀伤肿瘤的效果,随着肿瘤的进展,胆道再发梗阻发病率非常高。近年来,^125I粒子联合胆道支架开始用于无法手术的恶性梗阻性黄疸的治疗,可明显延长患者生存期和支架通畅时间。本文就^125I粒子联合胆道支架治疗恶性梗阻性黄疸的研究进展作一综述,并对^125I粒子植入术临床应用的安全性及有效性作进一步论证,旨在为规范化开展^125I粒子植入术提供可靠依据。Malignant obstructive jaundice is the bile obstruction caused by the invasion of cholangiocarcinoma,pancreatic cancer or ampulla cancer.Because of the insidious onset and poor prognosis,most patients have already lost the opportunity of surgery.Biliary stent can quickly relieve jaundice symptoms and has become the preferred palliative treatment for malignant obstructive jaundice.However,common biliary stents do not kill the tumor,and as the tumor progresses,the incidence of recurrent biliary obstruction is very high.In recent years,^125I seeds combined with biliary stent have been used in the treatment of inoperable malignant obstructive jaundice,which can significantly prolong the survival time of patients and the unobstructed stent time.This article reviews the progress of ^125I seeds combined with biliary stent in the treatment of malignant obstructive jaundice.and further demonstrates the safety and effectiveness of clinical application in ^125I seeds implantation to provide a reliable basis for the standardization of ^125 I seeds implantation.

关 键 词：近距离放射 ^125I 支架 恶性梗阻性黄疸 

分 类 号：R575[医药卫生—消化系统]