胃底腺息肉和胃增生性息肉患者胃液中胃肠激素的变化  

Changes of gastrointestinal hormone in gastric juice of patients with fundic gland polyp and hyperplastic polyp

作　　者：常丽丽[1] 高鹤 王利民 李光跃[1] 王莉[1] 张淑梅[1] 张静[1] 杨慧君[1] CHANG Lili;GAO He;WANG Limin;LI Guangyao;WANG Li;ZHANG Shumei;ZHANG Jing;YANG Huijun(Department of Gastroenterology,Shijiazhuang Municipal First Hospital,Shijiazhuang,Hebei 050011,China)

机构地区：[1]河北省石家庄市第一医院消化内科,河北石家庄050011

出　　处：《检验医学与临床》2020年第20期2921-2923,2928,共4页Laboratory Medicine and Clinic

基　　金：河北省医学科学研究重点课题(ZL20140272)。

摘　　要：目的观察胃底腺息肉和胃增生性息肉患者胃液中胃肠激素的变化,探讨胃息肉的发病机制。方法选取胃底腺息肉和胃增生性息肉患者及对照者各124例,分别纳入胃底腺息肉组、胃增生性息肉组、对照组,采用酶联免疫吸附试验检测胃液中胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素-17、前列腺素E 2(PGE 2)、表皮生长因子(EGF)、黏蛋白(MUC)2和MUC5AC水平。结果(1)胃底腺息肉组和胃增生性息肉组患者胃液中PGⅠ水平与对照组相比,差异无统计学意义(P>0.05),胃底腺息肉组和胃增生性息肉组PGⅡ水平高于对照组(P<0.05)。(2)胃底腺息肉组和胃增生性息肉组患者胃液中胃泌素-17、EGF、MUC2水平均明显高于对照组(P<0.05)。(3)胃底腺息肉组和胃增生性息肉组患者胃液中PGE 2和MUC5AC水平均低于对照组(P<0.05)。结论胃底腺息肉和胃增生性息肉患者存在胃肠激素分泌紊乱,胃液中胃泌素-17、EGF、MUC2水平升高,PGE 2和MUC5AC水平降低,这可能是导致胃底腺息肉和胃增生性息肉形成的关键因素,其确切发病机制尚需进一步研究。Objective To observe the changes of gastrointestinal hormone of gastric juice in the patients with gastric fundic gland polyp and gastric hyperplastic polyp,and to investigate the pathogenisis of gastric polyps.Methods Each 124 cases of gastric juice sample were selected from the patients with gastric fundic gland polyp(gastric fundic gland polyp group)and gastric hyperplastic polyp(gastric hyperplastic polyp group)and controls(control group).The enzyme linked immunosorbent assay(ELISA)was adopted to detect the levels of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),gastrin-17(G-17),epidermal growth factor(EGF),PGE 2,mucin(MUC)2 and MUC5AC.Results(1)The level of gastric juice PGⅠhad no statistical difference between the gastric fundic gland polyp group and gastric hyperplastic polyp group with the control group(P>0.05);the gastric juice PGⅡlevel in the gastric fundic gland polyp group and gastric hyperplastic polyp group was higher than that in the control group(P<0.05).(2)The levels of gastric juice gastrin-17,EGF and MUC2 in the gastric fundic gland polyp group and gastric hyperplastic polyp group were significantly higher than those in the control group(P<0.05).(3)The levels of gastric juice PGE 2 and MUC5AC in the gastric fundic gland polyp group and gastric hyperplastic polyp group were lower than those in the control group(P<0.05).Conclusion The disorder of gastrointestinal hormone secretion exists in the patients with gastric fundic gland polyp and gastric hyperplastic polyp.The levels of G-17,EGF and MUC2 are increased and the levels of PGE 2 and MUC5AC in gastric juice are decreased,which may be the key factors leading to the formation of gastric fundic gland polyp and gastric hyperplastic polyp,but its definite pathogensis needs to be further studied.

关 键 词：胃底腺息肉 胃增生性息肉 胃液 胃肠激素 

分 类 号：R573.9[医药卫生—消化系统]