痴呆和非痴呆患者血浆鸢尾素含量比较  

Comparison of plasma irisin levels between patients with and without dementia

作　　者：张伟彬 阮清伟[1] 姚锋 俞卓伟[1] Zhang Weibin;Ruan Qingwei;Yao Feng;Yu Zhuowei(Department of Geriatrics,Institute of Gerontology and Geriatrics of Shanghai City,Key Laboratory of Clinical Geriatric Medicine of Shanghai City,Huadong Hospital Affiliated to Fudan University,Shanghai,200040;Zhongren Geriatric Care Hospital,Jinshan District,Shanghai,201501,P.R.China)

机构地区：[1]复旦大学附属华东医院老年科,上海市老年医学研究所,上海市老年医学临床重点实验室,上海200040 [2]上海市金山区众仁老年护理医院,上海201501

出　　处：《老年医学与保健》2020年第5期826-829,共4页Geriatrics & Health Care

基　　金：上海市科学技术委员会医学科学技术支持项目(18411962200);上海市申康发展中心项目(SHDC12014221);上海市卫计委重要薄弱学科建设-老年医学(2015ZB0501)。

摘　　要：目的比较痴呆患者与非痴呆患者的血浆鸢尾素水平,同时探讨躯体活动受限、阿尔兹海默病(AD)及血管性痴呆(VD)对血浆鸢尾素含量的影响。方法收集77例痴呆患者和49例非痴呆患者病史和血浆样本,采用ELISA方法测定其鸢尾素含量。结果痴呆患者平均年龄为(84.1±7.2)岁,活动受限比率42.8%。非痴呆患者的平均年龄为(80.2±9.9)岁,活动受限比率为67.3%,活动受限差异有统计学意义(P=0.022)。痴呆患者血浆鸢尾素水平(11.54±7.14)ng/m L低于非痴呆患者(12.45±5.94)ng/mL,差异无统计学意义(P=0.458)。痴呆患者中,受限(11.47±6.30)ng/mL和非受限患者血浆鸢尾素(11.60±7.78)ng/mL的差异均无统计学意义(P=0.914)。而在非痴呆患者中,非活动受限患者的血浆鸢尾素水平(17.72±8.04)ng/mL较受限患者(9.90±1.43)ng/mL高。差异有统计学意义(P<0.001)。校正年龄和性别因素后,血浆鸢尾素水平是非痴呆患者受限与否的独立风险因素。AD[10.46(8.30,12.41)]和VD[9.88(7.25,13.19)]受试者的血浆鸢尾素水平差异无统计学意义(P=0.970)。结论痴呆患者较非痴呆老年人血浆鸢尾素水平低,但是差异无统计学意义,可能是由于2组间受限的比率差异过大。慢性躯体活动受限会降低非痴呆患者肌源性鸢尾素的分泌。由于血脑屏障损害,活动受限对痴呆患者血浆鸢尾素水平的影响较小。要扩大样本量进一步对结果进行验证。无痴呆老年人应增强体育锻炼,从而促进肌源性鸢尾素水平,预防认知功能下降。Objective To compare plasma irisin level between patients with and without dementia,and to explore the effect of physical activity restriction,Alzheimer’s disease(AD)and vascular dementia(VD)on the levels of plasma irisin.Methods A total of 77 subjects with dementia and 49 ones without dementia were recruited and their medical history and plasma sample were collected.The level of plasma irisin were detected by ELISA method.Results The average age of dementia subjects was(84.1±7.2)years,and the rate of physical activity restriction was 42.8%;The average age of non-dementia subjects was(80.2±9.9)years,and the rate of physical activity restriction was 67.3%.Differences in the rate of physical activity restriction between two groups was statistically significant(P=0.022).Plasma irisin level of subjects with dementia(11.54±7.14 ng/mL)were lower than that of subjects without dementia(12.45±5.94 ng/mL),but the difference was not statistically significant(P=0.458).In dementia patients,there was no significant difference in plasma irisin level between patients with physical activity restriction(11.47±6.30 ng/mL)and ones without physical activity restriction(11.60±7.78 ng/mL)(P=0.914).In non-dementia patients,plasma irisin level in patients without physical activity restriction(17.72±8.04 ng/mL)was higher than that in ones with physical activity restriction(9.90±1.43 ng/mL.),and the difference was statistically significant(P<0.001).After adjusting for age and gender factors,plasma irisin level was an independent risk factor for physical activity restriction in non-dementia patients.There was no significant difference in plasma irisin levels between AD[10.46(8.30,12.41)]and VD[9.88(7.25,13.19)]patients(P=0.970).Conclusion Dementia patients have lower plasma irisin levels than non-dementia elderly people,but the difference is not statistically significant,which may be due to the large difference in the physical activity restriction ratio between the two groups.Chronic physical activity restriction reduces myogenic

关 键 词：老年性痴呆 鸢尾素 血管性痴呆 躯体活动受限 

分 类 号：R749.16[医药卫生—神经病学与精神病学]