Primary rhabdomyosarcoma: An extremely rare and aggressive variant of male breast cancer  

作　　者：Catalin Bogdan Satala Ioan Jung Tivadar Jr Bara Patricia Simu Iunius Simu Madalina Vlad Rita Szodorai Simona Gurzu 

机构地区：[1]Department of Pathology,Clinical County Emergency Hospital,Tirgu Mures 540139,Romania [2]Department of Pathology,George Emil Palade University of Medicine,Pharmacy,Sciences and Technology,Targu Mures 530149,Romania [3]Department of Surgery,Clinical County Emergency Hospital,Targu Mures 540136,Romania [4]Department of Radiology,George Emil Palade University of Medicine,Pharmacy,Sciences and Technology,Targu Mures 530149,Romania [5]Department of Pathology,Clinical County Emergency Hospital,Targu Mures 540136,Romania [6]Department of Pathology,George Emil Palade University of Medicine,Pharmacy,Science and Technology,Targu Mures 530149,Romania [7]Research Center(CCAMF),University of Medicine,Pharmacy,Sciences and Technology,Targu Mures 540139,Romania

出　　处：《World Journal of Clinical Cases》2020年第19期4466-4474,共9页世界临床病例杂志

摘　　要：BACKGROUND Rhabdomyosarcoma(RMS)of the breast,a mesenchymal neoplasm with skeletal muscle differentiation,is an extremely rare tumour in males,with less than 30 cases published in English-language literature.We report on the first case of a male breast RMS,with an unusual ectomesenchymal/neuroectodermal component.CASE SUMMARY A 55-year-old,previously healthy male,underwent a radical left mastectomy for an ulcerated tumour mass,occupying the breast and left anterior thoracic wall.The biopsy specimen indicated the presence of a tumour with neural origins,namely a peripheral neuroectodermal tumour(PNET).The surgical specimens identified two components.The rhabdomyosarcomatous component(over 70%)was represented by large pleomorphic cells with positivity for desmin,sarcomeric actin and myogenin.The PNET-like ectomesenchymal component,which was admixed with the RMS cells,and was also revealed during the preoperative biopsy,consisted of small cells which expressed neurofilament,neuron specific enolase and CD99.The microscopic examination,along with the immunohistochemical profile,allowed the diagnosis of an RMS,with unusual ectomesenchymal differentiation.The patient refused the postoperative oncologic therapy and died three months after surgery.CONCLUSION In patients with RMS of the breast,the PNET-like ectomesenchymal component increases the diagnosis difficulty,especially in biopsy specimens.This differentiation can be immunohistochemically proven and might highlight the possible development of high-grade sarcoma of the breast from remnants of the embryological ectodermal layer.

关 键 词：Mammary gland RHABDOMYOSARCOMA Ectomesenchymoma Male Case report CD99 

分 类 号：R73[医药卫生—肿瘤]