Extremely rare case of successful treatment of metastatic ovarian undifferentiated carcinoma with high-dose combination cytotoxic chemotherapy: A case report  

作　　者：Hong Beum Kim Hee Jeong Lee Ran Hong Sang-Gon Park 

机构地区：[1]Department of Premedical Course,Chosun University School of Medicine,Gwngju 505717,South Korea [2]Department of Internal Medicine,Hemato-oncology,Chosun University Hospital,Gwangju 505717,South Korea [3]Department of Pathology,Chosun University Hospital,Gwangju 505717,South Korea

出　　处：《World Journal of Clinical Cases》2020年第19期4488-4493,共6页世界临床病例杂志

基　　金：the National Research Foundation of Korea,funded by the Ministry of Science,ICT,and Future Planning,No.NRF-2017R1D1A1B04031741;and grants from the Chosun University Hospital,No.2019.

摘　　要：BACKGROUND Ovarian undifferentiated carcinomas are significantly rare and have an aggressive clinical course.Surgical resection is the only curative treatment in early-stage ovarian undifferentiated carcinomas that has a favorable prognosis.In case of recurrent and metastatic disease,palliative chemotherapy is the only available treatment.However,the effectiveness of standard chemotherapy regimen is not well-known,specifically in the case of extra-ovarian spread.We report an ovarian undifferentiated carcinoma of recurrent and inoperable advanced stage that was successfully treated with high-dose combination chemotherapy.CASE SUMMARY A 52-year-old woman presented with a 1-mo history of right lower quadrant and epigastric pain.A computed tomography(CT)scan of the abdomen revealed a multicystic mass with extensive internal necrosis of the right ovary without evidence of metastatic disease.A total hysterectomy with bilateral salpingooophorectomy and omentectomy was performed,but the surgery had a positive resection margin.Pathologically,it was diagnosed as ovarian undifferentiated carcinoma with sarcomatoid change.Although adjuvant chemotherapy was planned,it was delayed for 6 wk because of postoperative recovery,and the patient complained of abdominal pain.A CT scan and positron emission tomography-CT revealed a huge mass with multiple nodules in the pelvic cavity and para-aortic lymph node metastasis.Instead of standard therapy such as paclitaxel and platinum,combined chemotherapy with etoposide,ifosfamide,and cisplatin was administered.The patient experienced no recurrence for 5 years.CONCLUSION This is a case of metastatic ovarian undifferentiated carcinoma with sarcomatoid change that was successfully treated with high-dose combination cytotoxic chemotherapy.

关 键 词：Ovarian undifferentiated carcinoma Sarcomatoid change Chemotherapy Etoposide ifosfamide cisplatin Case report 

分 类 号：R737.31[医药卫生—肿瘤]