MRP-8/14在侵袭性牙周炎患者唾液和血清中的表达及其意义  

The expression and significance of MRP-8/14 in saliva and serum of patients with aggressive periodontitis

作　　者：周智妍 郭敬茹 马平[1] 杨帆 ZHOU Zhiyan;GUO Jingru;MA Ping;YANG Fan(Department of Stomatology,Tiding Central Hospital,Tieling 112000,China)

机构地区：[1]铁岭市中心医院口腔科,辽宁铁岭112000

出　　处：《现代医学》2020年第6期685-690,共6页Modern Medical Journal

基　　金：辽宁省科学技术计划项目(2017225084)。

摘　　要：目的:探讨髓细胞相关蛋白-8/14(MRP-8/14)在侵袭性牙周炎患者唾液和血清中的表达及其意义。方法:选取2017年1月至2019年3月我院收治的侵袭性牙周炎患者85例作为观察组,另选取同期健康体检者69例作为对照组,对受试人员进行牙周检查,统计相应指标,并采用酶联免疫吸附测定法(ELISA)检测MRP-8/14水平,比较两组牙周情况,Pearson法分析MRP-8/14在唾液和血清中表达水平与平均探诊深度(MPD)、探诊出血(BOP)的相关性,受试者工作特征曲线(ROC曲线)分析患者唾液和血清中MRP-8/14水平的诊断价值。结果:观察组探诊深度(PD)、附着丧失(AL)、BOP显著高于对照组(P<0.05);观察组唾液流速、非刺激性全唾液pH水平显著低于对照组,刺激性全唾液比例、刺激性全唾液MRP-8/14水平、血清中MRP-8/14水平、刺激性全唾液钙水平、血清钙水平显著高于对照组(P<0.05);观察组患者唾液MRP-8/14表达水平与MPD、BOP呈正相关,且血清MRP-8/14表达水平也与MPD、BOP呈正相关(均P<0.05);ROC曲线分析结果显示唾液MRP-8/14水平诊断价值高于血清MRP-8/14水平诊断价值,唾液MRP-8/14的敏感度为85.40%、特异度为62.22%、约登指数为0.476;血清MRP-8/14的敏感度为77.10%、特异度为56.80%、约登指数为0.339。结论:侵袭性牙周炎患者唾液和血清中MRP-8/14水平均明显升高,且唾液和血清中的MRP-8/14表达均与MPD、BOP紧密相关,在侵袭性牙周炎发生过程中起到重要作用。Objective:To investigate the expression and significance of myeloid-related protein-8/14(MRP-8/14)in saliva and serum of patients with aggressive periodontitis.Methods:85 patients with aggressive periodontitis treated in our hospital from January 2017 to March 2019 were selected as observation group,and 69 cases of healthy physical examination were selected as control group in the same period,periodontal examination was performed on the subjects,and the corresponding indicators were recorded,the level of MRP-8/14 was detected by enzymelinked immunosorbent assay(ELISA),amd the periodontal condition of the two groups was compared,the correlation between MRP-8/14 expression level with average depth of exploration(MPD)and bleeding on probing(BOP)in saliva and serum was analyzed by Pearson method,the diagnostic value of MRP-8/14 in saliva and serum was analyzed by receiver operating characteristic curve(ROC).Results:The probing depth(PD),attachment loss(AL)and BOP in the observation group were significantly higher than those in the control group(P<0.05);the saliva flow rate and non irritating total saliva p H level in the observation group were significantly lower than those in the control group,the proportion of irritating total saliva,irritating total saliva MRP-8/14 level,serum MRP-8/14 level,irritating total saliva calcium level and serum calcium level were significantly higher than those in the control group(P<0.05);the expression of MRP-8/14 in saliva was positively correlated with MPD and BOP in the observation group,and the expression of MRP-8/14 in serum was positively correlated with MPD and BOP(all P<0.05);the results of ROC analysis showed that the diagnostic value of saliva MRP-8/14 was higher than the diagnostic value of serum MRP-8/14,the sensitivity of saliva MRP-8/14 was 85.40%,the specificity was 62.22%,and the Youden index was 0.476;the sensitivity of serum MRP-8/14 was 77.10%,the specificity was 56.80%,and the Youden index was 0.339.Conclusion:The levels of MRP-8/14 in saliva and serum were signifi

关 键 词：髓细胞相关蛋白-8/14 侵袭性牙周炎 唾液 血清 探诊深度 探诊出血 

分 类 号：R781.42[医药卫生—口腔医学]