BACH1在胃癌中的表达及其临床意义  

The expression and clinical significance of BACH1 in gastric cancer

作　　者：陈冲[1] 周波[1] 常家聪[1] Chen Chong;Zhou Bo;Chang Jiacong(Dept of General Surgery,The First Affiliated Hospital of Anhut Mepical University,Hefei 230032)

机构地区：[1]安徽医科大学第一附属医院普外科,合肥230022

出　　处：《安徽医科大学学报》2020年第10期1575-1578,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81801952);安徽省自然科学基金(编号:1708085QH199)。

摘　　要：目的探讨BTB-CNC异体同源体1(BACH1)在胃癌中的表达情况及其与临床病理特征和预后的关系。方法使用含98例胃癌病例样本且携带临床病理特征及随访信息的胃癌组织芯片,采用免疫组化方法检测BACH1的表达情况并分析其与胃癌患者临床病理特征及预后之间的关系。结果BACH1在胃癌组织中阳性表达率(44.9%)高于癌旁正常组织(25.6%)(P<0.05),且和胃癌的病理分级、T分期、淋巴结转移及TNM分期均相关(P<0.05)。K-M生存分析显示BACH1高表达患者预后更差(P<0.05),COX生存分析显示BACH1表达、淋巴结转移、远处转移和TNM分期是胃癌不良预后的预测因素(均P<0.05),且BACH1表达(P=0.028)和远处转移(P=0.001)是胃癌预后的独立危险因素。结论BACH1的异常表达与胃癌的发生发展密切相关,可能是胃癌患者预后的潜在生物标志物。Objective To investigate the expression of BTB and CNC homology 1(BACH1) in gastric cancer and its relationship with clinicopathological features and prognosis.Methods Gastric cancer microarray containing 98 samples of gastric cancer with clinicopathological features and follow-up information was used to detect the expression of BACH1 by immunohistochemical method. And the relationship between the expression of BACH1 and the clinicopathological features and prognosis of gastric cancer patients was analyzed.Results The positive expression rate of BACH1 in gastric cancer tissues(44.9%) was higher than that in adjacent normal tissues(25.6%)(P<0.05), which was closely correlated with the pathological grade, T stage, lymph node metastasis and TNM stage of tumor(all P<0.05). K-M survival analysis showed that patients with high expression of BACH1 had a worse prognosis(P<0.05). COX survival analysis showed that the expression of BACH1, lymph node metastasis, distant metastasis and TNM stage were predictors of poor prognosis for gastric cancer(all P<0.05), and the expression of BACH1(P=0.028) and distant metastasis(P=0.001) were independent risk factors for the prognosis of gastric cancer patients.Conclusion The abnormal expression of BACH1 is closely related to the occurrence and development of gastric cancer,which may be a potential biomarker for the prognosis of gastric cancer patients.

关 键 词：胃癌 BACH1 组织芯片 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]